Broussonin E MedChemExpress (MCE)

Product Name	Broussonin E
Synonyms	Broussonin E;2-[3-(3-Hydroxy-4-methoxyphenyl)propyl]-5-methoxyphenol;Phenol,2-[3-(3-hydroxy-4-methoxyphenyl)- propyl]-5-methoxy-
CAS	90902-21-9
EINECS
Chemical Formula	C17H20O4
Molecular Weight	288.34
inchi
Package	10 mM * 1 mL;5 mg;10 mg;25 mg
Price	Email to quote
Descriptions	Broussonin E Broussonin E MedChemExpress (MCE) HY-N2963 90902-21-9 98.18% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Broussonin E Broussonin E MedChemExpress (MCE) HY-N2963 90902-21-9 98.18% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Broussonin E is a phenolic compound and shows anti-inflammatory activity. Broussonin E can suppress inflammation by modulating macrophages activation statevia inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway. Broussonin E can be used for the research of inflammation-related diseases such as atherosclerosis. Broussonin E (20 μM, 3 h) inhibits the LPS (Lipopolysaccharides, HY-D1056)-stimulated phosphorylation of ERK and p38 MAPK[1]. Broussonin E can activate janus kinase (JAK) 2, signal transducer and activator of transcription (STAT) 3[1]. Broussonin E (0-20 μM, 3 h) can suppress the LPS-induced pro-inflammatory production in RAW264.7 cells, involving TNF-α, IL-1β, IL-6, COX-2 and iNOS[1]. Broussonin E enhances the expressions of anti-inflammatory mediators such as IL-10, CD206 and arginase-1 (Arg-1) in LPS-stimulated RAW264.7 cells[1]. ERK p38 MAPK JAK2 STAT3 IL-1β IL-6 COX-2 IL-10 \| \| \| \| \| \| \| \| \| \| [1]. Huang SP, et al. Broussonin E suppresses LPS-induced inflammatory response in macrophages via inhibiting MAPK pathway and enhancing JAK2-STAT3 pathway. Chin J Nat Med. 2019 May 20 17(5):372-380. [Content Brief]
Supplier Website	https://www.medchemexpress.com/broussonin-e.html
Last Update	2025-05-21 16:50:25

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