Moracin CMoracin C
MedChemExpress (MCE)
HY-N3245
69120-06-5
99.54%
4°C, protect from light *In solvent : -80°C, 6 months
-20°C, 1 month (protect from light)
Room temperature in continental US
may vary elsewhere.
Moracin C, a natural product, is an anti-inflammatory agent. Moracin C inhibits LPS-activated reactive oxygen species (ROS) and nitric oxide (NO) release from cells.
Moracin C (1-50 μM, 24 h) inhibits LPS-activated reactive oxygen species (ROS) and nitric oxide (NO) release from RAW264.7 cells[1]. Moracin C (1-50 μM, 2 h) inhibits mRNA and protein expression of iNOS and COX-2 in RAW264.7 cells[1]. Moracin C (1-50 μM, 2 h) inhibits pro-inflammatory cytokine (IL-1β, IL-6 and TNF-α) productions in LPS-activated RAW 264.7 cells[1]. Moracin C (1-50 μM, 2 h) inhibits phosphorylation of p38, ERK and JNK in LPS-activated RAW 264.7 cells[1].
Moracin C (100 mg/kg, oral gavage, mice) was rapidly and well absorbed in the intestinal tract, and was highly distributed in the gastrointestinal tract, liver, kidneys, and lungs[2].
COX-2
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[1]. Yao X, et al. Moracin C, A Phenolic Compound Isolated from Artocarpus heterophyllus, Suppresses Lipopolysaccharide-Activated Inflammatory Responses in Murine Raw264.7 Macrophages. Int J Mol Sci. 2016 Jul 25
17(8):1199. [Content Brief]
[2]. You BH, et al. Pharmacokinetic Properties of Moracin C in Mice. Planta Med. 2021 Jul
87(8):642-651. [Content Brief]