Amantadine-d6 MedChemExpress (MCE)

Product Name
Synonyms	[2H6]-Amantadine;Adamantanamine-d6;1-Aminoadamantane-2,2,2′,2′,2″,2″-d6;Amantadine-d6 (1-Amino Adamantane-d6)
CAS	1219805-53-4
EINECS
Chemical Formula	C10H17N
Molecular Weight	151.25
inchi
Package	1 mg
Price	Email to quote
Descriptions	Amantadine-d6 Amantadine-d6 MedChemExpress (MCE) HY-B0402S1 1219805-53-4 1-Adamantanamine-d6 Descriptions Amantadine-d6 Amantadine-d6 MedChemExpress (MCE) HY-B0402S1 1219805-53-4 1-Adamantanamine-d6 1-Aminoadamantane-d6 98.10% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Amantadine-d6 is the deuterium labeled Amantadine[1]. Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine also has anti-orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson's disease, postoperative cognitive dysfunction (POCD) and COVID-19 research[2][3][4][5][6][7]. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. \| \| \| \| \| \| \| \| \| \| [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb 53(2):211-216. [Content Brief] [2]. Suzuki H, et al. Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother. 2003 9(3):195-200. [Content Brief] [3]. Hubsher G, et al. Amantadine: the journey from fighting flu to treating Parkinson disease. Neurology. 201278(14):1096-1099. [Content Brief] [4]. Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan57(1-2):41-52. [Content Brief] [5]. Fink K, et al. Amantadine Inhibits SARS-CoV-2 In Vitro. Viruses. 2021 Mar 2413(4):539. [Content Brief] [6]. Zhang J, et al. Amantadine alleviates postoperative cognitive dysfunction possibly by increasing glial cell line-derived neurotrophic factor in rats. Anesthesiology. 2014 Oct121(4):773-85. [Content Brief] [7]. Lan Z, et al. Amantadine inhibits cellular proliferation and induces the apoptosis of hepatocellular cancer cells in vitro. Int J Mol Med. 201536(3):904-910. [Content Brief]
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Last Update	2025-04-01 14:45:47

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