Isoangustone A MedChemExpress (MCE)

Product Name	Isoangustone A
Synonyms	Isoangustone A 3-[3,4-Dihydroxy-5-(3-methyl-2-buten-1-yl)phenyl]-5,7-dihydroxy-6-(3-methyl-2-buten-1-yl)-4H-chromen-4-one 3-[3,4-Dihydroxy-5-(3-methyl-2-buten-1-yl)phenyl]-5,7-dihydroxy-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one Synonyms Isoangustone A 3-[3,4-Dihydroxy-5-(3-methyl-2-buten-1-yl)phenyl]-5,7-dihydroxy-6-(3-methyl-2-buten-1-yl)-4H-chromen-4-one 3-[3,4-Dihydroxy-5-(3-methyl-2-buten-1-yl)phenyl]-5,7-dihydroxy-6-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one 4H-1-Benzopyran-4-one, 3-[3,4-dihydroxy-5-(3-methyl-2-buten-1-yl)phenyl]-5,7-dihydroxy-6-(3-methyl-2-buten-1-yl)-
CAS	129280-34-8
EINECS
Chemical Formula	C25H26O6
Molecular Weight	422.47
inchi
Package	1 mg
Price	Email to quote
Descriptions	Isoangustone A Isoangustone A MedChemExpress (MCE) HY-N4006 129280-34-8 96.0% -20°C, protect from light In solvent : -80°C, 6 months Descriptions Isoangustone A Isoangustone A MedChemExpress (MCE) HY-N4006 129280-34-8 96.0% -20°C, protect from light In solvent : -80°C, 6 months -20°C, 1 month (protect from light) Room temperature in continental US may vary elsewhere. Isoangustone A is an anticancer and anti-inflammatory agent. Isoangustone A induces cancer cells apoptosis and autophagic cell death. Isoangustone A (10 and 20 μM 48 and 72 h) suppresses proliferation and induces G1 phase cell cycle arrest in SK-MEL-28 cells[1]. Isoangustone A (10 and 20 μM 48 h) decreases the abundance of G1 phase-related proteins mediated through the Akt/GSK3β and MKK4/MKK7/JNKs signaling pathways[1]. Isoangustone A suppresses PI3-K, MKK4, and MKK7 kinase activities by directly binding in an ATP-competitive manner[1]. Isoangustone A (20 μM 0.5-4 h) induces autophagy in colorectal cancer cells by activating AMPK signaling[2]. Isoangustone A (1-20 μM 0-100 min) inhibits mitochondrial respiration[2]. Isoangustone A (15 μM 6 h) induces SW480 cells apoptosis[2]. Isoangustone A (1-20 μΜ 3 days) suppresses mesangial fibrosis and inflammation in human renal mesangial cells[3]. Isoangustone A (2 or 10 mg/kg i.p. daily for 35 days) significantly decreases tumor growth, volume, and weight of SK-MEL-28 xenografts in mice[1]. Apoptosis, Autophagy[2] Cellular Effect Cell Line Type Value Description References \| \| \| \| \| \| \| \| \| \| [1]. Song NR, et al. Isoangustone A, a novel licorice compound, inhibits cell proliferation by targeting PI3K, MKK4, and MKK7 in human melanoma. Cancer Prev Res (Phila). 2013 Dec 6(12):1293-303. [Content Brief] [2]. Tang S, et al. Isoangustone A induces autophagic cell death in colorectal cancer cells by activating AMPK signaling. Fitoterapia. 2021 Jul 152:104935. [Content Brief] [3]. Li J, et al. Isoangustone A suppresses mesangial fibrosis and inflammation in human renal mesangial cells. Exp Biol Med (Maywood). 2011 Apr 1 236(4):435-44. [Content Brief]
Supplier Website	https://www.medchemexpress.com/isoangustone-a.html
Last Update	2025-05-21 16:50:25

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