Manganese chloride (tetrahydrate), molecular biology grade,≥99.0% (KT) MedChemExpress (MCE)

Product Name	Manganese(II) chloride tetrahydrate
Synonyms	Manganese (Ii) Fluoride MANGANESE (II) CHLORIDE MANGANESE(II) CHLORIDE 4H2O Manganese(Ii) Chloride 4H2O Manganouschloride,Tetrahydrat Manganouschloride,tetrahydrat Manganese Chloride, 4-Hydrate Synonyms Manganese (Ii) Fluoride MANGANESE (II) CHLORIDE MANGANESE(II) CHLORIDE 4H2O Manganese(Ii) Chloride 4H2O Manganouschloride,Tetrahydrat Manganouschloride,tetrahydrat Manganese Chloride, 4-Hydrate Manganese Chloride Tetrahydrate Manganese(Ii) Chloride-4-Hydrate MANGANESE(II) CHLORIDE-4-HYDRATE Manganese(Ⅱ)Chloride Tetrahydrate Manganese Dichloride Tetrahydrate Manganese(+2)Chloride Tetrahydrate MANGANESE(+2)CHLORIDE TETRAHYDRATE MANGANESE(II) CHLORIDE TETRAHYDRATE Manganese(II) chloride tetrahydrate MANGANESE CHLORIDE TETRAHYDRATE INSE Manganese(II) chloride tetrahydrate for analysis EMSURE ACS
CAS	13446-34-9
EINECS	603-826-5
Chemical Formula	Cl2H8MnO4
Molecular Weight	197.91
inchi	InChI=1/ClH.Mn.4H2O/h1H;;4*1H2/q;+2;;;;/p-1
Package	5 g
Price	Email to quote
Descriptions	Manganese chloride (tetrahydrate), molecular biology grade,≥99.0% (KT) Manganese chloride (tetrahydrate), molecular biology grade,≥99.0% (KT) MedChemExpress (MCE) HY-109521A 13446-34-9 Manganese(Ⅱ) chloride (tetrahydrate), molecular biology grade,≥99.0% (KT) 99.08% 4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months Descriptions Manganese chloride (tetrahydrate), molecular biology grade,≥99.0% (KT) Manganese chloride (tetrahydrate), molecular biology grade,≥99.0% (KT) MedChemExpress (MCE) HY-109521A 13446-34-9 Manganese(Ⅱ) chloride (tetrahydrate), molecular biology grade,≥99.0% (KT) 99.08% 4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture and light) Room temperature in continental US may vary elsewhere. Manganese chloride (tetrahydrate), molecular biology grade,≥99.0% (KT) is an orally active and a blood-brain barrier penetrant compound. It affects the activities of multiple enzymes in cells, such as regulating the activities of histone acetyltransferase (HAT) and histone deacetylase (HDAC), thereby affecting gene expression. It has multiple activities such as neurotoxicity, embryotoxicity, and reproductive toxicity. It is currently mainly used in neurodegenerative diseases and toxicology research. Manganese chloride tetrahydrate, molecular biology grade,≥99.0% (KT) (15-25 μM) shows cytotoxicity and causes chromosomal aberrations as well as DNA damage in cultured human lymphocytes[1]. Manganese chloride (300 μM 3-24 h) tetrahydrate, molecular biology grade, ≥99.0% (KT) can significantly inhibit the acetylation of histones H3 and H4 and change the activities and expression levels of HAT and HDAC in PC12 cells and SH-SY5Y cells[2]. Manganese chloride (0.1-10 mM 5 days) tetrahydrate, molecular biology grade,≥99.0% (KT) reduces cell viability and inhibits the differentiation of cells into cartilage nodules in micromass cultures of mouse embryonic limb bud cells[3]. Manganese chloride (1000 - 8000 mg/l ingested through drinking water, p.o. for 12 weeks) tetrahydrate, molecular biology grade, ≥99.0% (KT) reduces the fertility of male Swiss mice and decreases the number of implantation sites and viable fetuses in female Swiss mice at a high concentration (8000 mg/l)[4]. Manganese chloride (0-100 mg/kg s.c. single-dose or multiple-dose 1 day or 7 days) tetrahydrate, molecular biology grade, ≥99.0% (KT) significantly increases the manganese concentration in the basal ganglia and causes a decrease in horizontal movement in C57BL/6 mice[5]. Manganese chloride (0-50 mg/kg p.o. once a day 21 days) tetrahydrate, molecular biology grade, ≥99.0% (KT) reduces body weight gain and increases the amplitude of the acoustic startle response in neonatal CD rats, and increases striatal, cerebellar and brain residue manganese concentrations in adult CD rats at high doses[6]. Manganese chloride (16 mg/kg/day i.v. once a day 4 days) tetrahydrate, molecular biology grade, ≥99.0% (KT) leads to the death or moribund sacrifice of male beagle dogs, with severe hepatotoxicity, hypotension and reflex tachycardia[7]. \| \| \| \| \| \| \| \| \| \| [1]. Lima PD, et al. Genotoxic and cytotoxic effects of manganese chloride in cultured human lymphocytes treated in different phases of cell cycle. Toxicol In Vitro. 2008 Jun 22(4):1032-7. [Content Brief] [2]. Guo Z, et al. Manganese chloride induces histone acetylation changes in neuronal cells: Its role in manganese-induced damage. Neurotoxicology. 2018 Mar 65:255-263. [Content Brief] [3]. Doyle D, et al. Inhibition of cell differentiation by manganese chloride in micromass cultures of mouse embryonic limb bud cells. Toxicol In Vitro. 2002 Apr 16(2):101-6. [Content Brief] [4]. Elbetieha A, et al. Effects of long-term exposure to manganese chloride on fertility of male and female mice. Toxicol Lett. 2001 Mar 8 119(3):193-201. [Content Brief] [5]. Dodd CA, et al. Basal Ganglia accumulation and motor assessment following manganese chloride exposure in the C57BL/6 mouse. Int J Toxicol. 2005 Nov-Dec 24(6):389-97. [Content Brief] [6]. Dorman DC, et al. Neurotoxicity of manganese chloride in neonatal and adult CD rats following subchronic (21-day) high-dose oral exposure. J Appl Toxicol. 2000 May-Jun 20(3):179-87. [Content Brief] [7]. Khan KN, et al. Toxicity of subacute intravenous manganese chloride administration in beagle dogs. Toxicol Pathol. 1997 Jul-Aug 25(4):344-50. [Content Brief]
Last Update	2025-04-01 14:45:47

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