Lys-[Des-Arg9]Bradykinin MedChemExpress (MCE)

Product Name	lys-des-arg9-bradykinin
Synonyms	des-arg(10)-kallidi (DES-ARG10)-KALLIDIN lys-des-arg9-bradykinin LYSYL-DES-ARG9-BRADYKININ LYS-(DES-ARG9)-BRADYKININ [DES-ARG9,LYS0]-BRADYKININ [LYS0, DES-ARG9]-BRADYKININ Synonyms des-arg(10)-kallidi (DES-ARG10)-KALLIDIN lys-des-arg9-bradykinin LYSYL-DES-ARG9-BRADYKININ LYS-(DES-ARG9)-BRADYKININ [DES-ARG9,LYS0]-BRADYKININ [LYS0, DES-ARG9]-BRADYKININ Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe LYS-ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE H-LYS-ARG-PRO-PRO-GLY-PHE-SER-PRO-PHE-OH
CAS	71800-36-7
EINECS
Chemical Formula	C50H73N13O11
Molecular Weight	1032.2
inchi	InChI=1/C50H73N13O11/c51-22-8-7-17-33(52)42(66)58-34(18-9-23-55-50(53)54)46(70)63-26-12-21-40(63)48(72)62-25-10-19-38(62)44(68)56-29-41(65)57-35(27-31-13-3-1-4-14-31)43(67)60-37(30-64)47(71)61-24-11-20-39(61)45(69)59-36(49(73)74)28-32-15-5-2-6-16-32/h1-6,13-16,33-40,64H,7-12,17-30,51-52H2,(H,56,68)(H,57,65)(H,58,66)(H,59,69)(H,60,67)(H,73,74)(H4,53,54,55)/t33-,34-,35-,36-,37-,38-,39-,40-/m0/s1
Package	1 mg
Price	Email to quote
Descriptions	Lys-[Des-Arg9]Bradykinin Lys-[Des-Arg9]Bradykinin MedChemExpress (MCE) HY-103295 71800-36-7 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions Lys-[Des-Arg9]Bradykinin Lys-[Des-Arg9]Bradykinin MedChemExpress (MCE) HY-103295 71800-36-7 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Lys-[Des-Arg9]Bradykinin, a naturally occurring kinin, is a potent and highly selective bradykinin B1 receptor agonist with a Ki of 0.12 nM, 1.7 nM and 0.23 nM for human, mouse and rabbit B1 receptors, respectively. Lys-[Des-Arg9]Bradykinin has low inhibitory activity on B2 receptors. Lys-[Des-Arg9]Bradykinin is formed by the proteolytic cleavage of bradykinin, exerts its effects through bradykinin B1 receptor (B1R)[1].Lys-[Des-Arg9]Bradykinin (Lda-BK 10 μM) enhances the secretion of IL-12p70 and inhibits the secretion of IL-12p40 by mature hMo-DCs. Pretreatment with Lys-[Des-Arg9]Bradykinin treatment reduces the migration of mature hMo-DCs toward medium alone, suggesting that Lys-[Des-Arg9]Bradykinin may inhibit the chemokinesis of mature hMo-DCs[1]. Lys-[Des-Arg9]Bradykinin (1 μg intra-artenal injection New Zealand White rabbits) treatment reduces peripheral vascular resistance in LPS-induced rabbits, but the effect is brief (T1/2 is 118-195 s)[3]. Lys-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe \| \| \| \| \| \| \| \| \| \| [1]. Rosalind Gulliver, et al. Lys-des[Arg9]-bradykinin alters migration and production of interleukin-12 in monocyte-derived dendritic cells. Am J Respir Cell Mol Biol. 2011 Sep 45(3):542-9. [Content Brief] [2]. L M Fredrik Leeb-Lundberg, et al. International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol Rev. 2005 Mar 57(1):27-77. [Content Brief] [3]. G Drapeau, et al. Hypotensive effects of Lys-des-Arg9-bradykinin and metabolically protected agonists of B1 receptors for kinins. J Pharmacol Exp Ther. 1991 Dec 259(3):997-1003. [Content Brief]
Supplier Website	https://www.medchemexpress.com/lys-des-arg9-bradykinin.html
Last Update	2025-05-21 16:50:25

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