Cholic acid sodium MedChemExpress (MCE)

Product Name	Sodium cholate
Synonyms	SODIUM CHOLATE;Sodium cholate;SODIUM CHOLEATE;SODIUM, (R)-4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-TRIHYDROXY-10,13-DIMETHYL-HEXADECAHYDRO-CYCLOPENTA[A]PHENANTHREN-17-YL)-PENTANOATE
CAS	361-09-1
EINECS	206-643-5
Chemical Formula	C24H39NaO5
Molecular Weight	430.55
inchi
Package	10 mM * 1 mL;100 mg
Price	Email to quote
Descriptions	Cholic acid sodium Cholic acid sodium MedChemExpress (MCE) HY-N0324A 361-09-1 Sodium cholate 99.72% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions Cholic acid sodium Cholic acid sodium MedChemExpress (MCE) HY-N0324A 361-09-1 Sodium cholate 99.72% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Cholic acid sodium is a major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. Cholic acid sodium is orally active. Cholic acid (1 mg/mL, 30 min) competitively binds Na+/taurocholate cotransporting polypeptide (NTCP) on HepG2 cells and significantly inhibits the uptake of Cholic acid (CA)-nanoliposomes (LPs)-Doxorubicin (DOX)-HCl, which indicates that CA-LPs-DOX-HCl are also uptaken via NTCP-mediated endocytosis pathway[1]. Cholic acid (1% (w/w) Cholic acid-supplemented diet p.o. 14 days) decreases SHP (small heterodimer partner) protein expression, potentially via the upregulation of miR142-3p. Cholic acid increases CYP2D6 expression and activity[2]. Human Endogenous Metabolite \| \| \| \| \| \| \| \| \| \| [1]. Li Y, et al. Mechanism of hepatic targeting via oral administration of DSPE-PEG-Cholic acid-modified nanoliposomes. Int J Nanomedicine. 2017 Feb 28 12:1673-1684. [Content Brief] [2]. Pan X, et al. Cholic acid Feeding Leads to Increased CYP2D6 Expression in CYP2D6-Humanized Mice. Drug Metab Dispos. 2017 Apr 45(4):346-352. [Content Brief]
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Last Update	2025-05-21 16:50:25

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