Dihydroberberine MedChemExpress (MCE)

Product Name	dihydroberberine
Synonyms	Nsc331264 Dihydroberbine dihydroberberine 9,10-Dimethoxy-2,3-(methylenedioxy)-13,13a-didehydrob 9,10-Dimethoxy-2,3-(methylenedioxy)-13,13a-didehydroberbine 5,8-Dihydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine Synonyms Nsc331264 Dihydroberbine dihydroberberine 9,10-Dimethoxy-2,3-(methylenedioxy)-13,13a-didehydrob 9,10-Dimethoxy-2,3-(methylenedioxy)-13,13a-didehydroberbine 5,8-Dihydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine 6H-1,3-benzodioxolo[5,6-a]benzo[g]quinolizine, 5,8-dihydro-9,10-dimethoxy- 9,10-Dimethoxy-5,8-dihydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline 9,10-DiMethoxy-6,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline
CAS	483-15-8
EINECS
Chemical Formula	C20H19NO4
Molecular Weight	337.37
inchi	InChI=1/C20H19NO4/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2/h3-4,7-9H,5-6,10-11H2,1-2H3
Package	5 mg;10 mg;25 mg
Price	Email to quote
Descriptions	Dihydroberberine Dihydroberberine MedChemExpress (MCE) HY-N1934 483-15-8 98.44% 4°C, sealed storage, away from moisture and light The compound is unstable in solutions, freshly prepared is recommended. Room temperature in continental US Descriptions Dihydroberberine Dihydroberberine MedChemExpress (MCE) HY-N1934 483-15-8 98.44% 4°C, sealed storage, away from moisture and light The compound is unstable in solutions, freshly prepared is recommended. Room temperature in continental US may vary elsewhere. Dihydroberberine is a naturally occurring isoquinoline alkaloid with anti-inflammatory, anti-atherosclerotic, hypolipidemic and anti-tumor activities. Dihydroberberine inhibits the human ether-related gene (hERG) channel and significantly reduces the expression of heat shock protein 90 (Hsp90) and its interaction with hERG. Dihydroberberine also blocks the TLR4/MyD88/NF-κB signaling pathway to reduce pro-inflammatory cytokines and immunoglobulins, and has inhibitory effects on DSS (HY-116282C)-induced experimental colitis. Dihydroberberine also increases the sensitivity of lung cancer to sunitinib (HY-10255A), with synergistic efficacy. Dihydroberberine has a synergistic effect with sunitinib, and when mixed together, it exhibits anti-cancer effects in human non-small cell lung cancer cell lines (NSCLC), A549, NCI-H460 and NCI-H1299 cells. Dihydroberberine (25 μM 48 h) inhibits NCI-H460 cell proliferation and colony formation[2].NCI-H460 cells were treated with a mixture (DCS) of Dihydroberberine (25 μM) and Sunitinib (2 μM) to arrest the cell cycle in the G1 phase. DCS regulates JNK/p38 MAPK signaling and plays a role in inducing apoptosis[2]. Dihydroberberine (250 mg/kg intragastric gavage, once every other day for 14 days) effectively inhibits tumor growth and proliferation in the mouse NCI-H460 xenograft model and exhibits synergistic with Sunitini[2]. HSP90 \| \| \| \| \| \| \| \| \| \| [1]. Yu D, et al. Inhibitory effects and mechanism of dihydroberberine on hERG channels expressed in HEK293 cells. PLoS One. 2017 Aug 1 12(8):e0181823. [Content Brief] [2]. Li C, et al. Dihydroberberine, an isoquinoline alkaloid, exhibits protective effect against dextran sulfate sodium-induced ulcerative colitis in mice. Phytomedicine. 2021 Sep 90:153631. [Content Brief]
Last Update	2025-04-01 14:45:47

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