Licochalcone B MedChemExpress (MCE)

Product Name	Licochalcone B
Synonyms	LICOCHALCONEB Licochalcone B Licoagrochalcone B 3,4,4'-Trihydroxy-2-Methoxychalcone 3,4,4'-Trihydroxy-2-methoxy-trans-chalcone (E)-3-(3,4-Dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-2-propen-1-one Synonyms LICOCHALCONEB Licochalcone B Licoagrochalcone B 3,4,4'-Trihydroxy-2-Methoxychalcone 3,4,4'-Trihydroxy-2-methoxy-trans-chalcone (E)-3-(3,4-Dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-2-propen-1-one (2E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one 2-Propen-1-one,3-(3,4-dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-, (2E)-
CAS	58749-23-8
EINECS
Chemical Formula	C16H14O5
Molecular Weight	286.28
inchi	InChI=1/C16H14O5/c1-21-16-11(5-9-14(19)15(16)20)4-8-13(18)10-2-6-12(17)7-3-10/h2-9,17,19-20H,1H3/b8-4+
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg
Price	Email to quote
Descriptions	Licochalcone B Licochalcone B MedChemExpress (MCE) HY-N0373 58749-23-8 99.93% 4°C, protect from light In solvent : -80°C, 6 months Descriptions Licochalcone B Licochalcone B MedChemExpress (MCE) HY-N0373 58749-23-8 99.93% 4°C, protect from light In solvent : -80°C, 6 months -20°C, 1 month (protect from light) Room temperature in continental US may vary elsewhere. Licochalcone B is an extract from the root of Glycyrrhiza uralensis. Licochalcone B inhibits amyloid β (42) self-aggregation (IC50=2.16 μM) and disaggregate pre-formed Aβ42 fibrils, reduce metal-induced Aβ42 aggregation through chelating metal ionsLicochalcone B inhibits phosphorylation of NF-κB p65 in LPS signaling pathway. Licochalcone B inhibits growth and induces apoptosis of NSCLC cells. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7‐NLRP3 interaction. Licochalcone B (IC50: 2.16 μM) inhibits self-mediated Aβ42 aggregation and disaggregates Aβ42 pre-formed fibrils[1]. Licochalcone B (0-12 μM, 48 h) reduces the ROS generation and protects cells from H2O2-induced cell death in SH-SY5Y cells[1]. Licochalcone B (10 μM, 1 h) inhibits LPS-induced NF-κB activation in RAW264.7 cells[2]. Licochalcone B (10 μM, 1 h) inhibits the LPS-induced phosphorylation of NF-κB p65 at serine 276, and inhibited the expression of TNFα and MCP-1[2]. Licochalcone B (0-20 μM, 24 or 48 h) inhibits human NSCLC cell growth[3]. Licochalcone B (1-25 mg/kg, oral gavage) alleviates oxidative stress of hepatotoxicity in mice induced by CCl4[5]. NLRP3 \| \| \| \| \| \| \| \| \| \| [1]. Cao Y, et al. Licochalcone B, a chalcone derivative from Glycyrrhiza inflata, as a multifunctional agent for the treatment of Alzheimer's disease. Nat Prod Res. 2018 Oct 22:1-4. [Content Brief] [2]. Jun-ichi Furusawa, et al. Glycyrrhiza inflata-derived chalcones, Licochalcone A, Licochalcone B and Licochalcone D, inhibit phosphorylation of NF-kappaB p65 in LPS signaling pathway. Int Immunopharmacol. 2009 Apr 9(4):499-507. [Content Brief] [3]. Ha-Na Oh, et al. Licochalcone B inhibits growth and induces apoptosis of human non-small-cell lung cancer cells by dual targeting of EGFR and MET. Phytomedicine. 2019 Oct 63:153014. [Content Brief] [4]. Qiang Li, et al. Licochalcone B specifically inhibits the NLRP3 inflammasome by disrupting NEK7-NLRP3 interaction. EMBO Rep. 2022 Feb 3 23(2):e53499. [Content Brief] [5]. Teng H, et al. Hepatoprotective effects of licochalcone B on carbon tetrachloride-induced liver toxicity in mice. Iran J Basic Med Sci. 2016 Aug 19(8):910-915. [Content Brief]
Last Update	2025-04-01 14:45:47

MedChemExpress (MCE) also provides

Glycyl-L-glutamine

Category: Natural Products
CAS: 13115-71-4
Last Update: 2025-04-01 14:45:47

Triose phosphate

Category: Natural Products
CAS: 591-57-1
Last Update: 2025-04-01 14:45:47

Lactyl-CoA

Category: Natural Products
CAS: 1926-57-4
Last Update: 2025-04-01 14:45:47

12(S)-HPETE

Category: Natural Products
CAS: 71774-10-2
Last Update: 2025-04-01 14:45:47

Pyrithiamine

Category: Natural Products
CAS: 534-64-5
Last Update: 2025-04-01 14:45:47

alpha-CEHC

Category: Natural Products
CAS: 4072-32-6
Last Update: 2025-04-01 14:45:47

Maltoheptaose

Category: Natural Products
CAS: 34620-78-5
Last Update: 2025-04-01 14:45:47

Phenoxyethanol

Category: Natural Products
CAS: 122-99-6
Last Update: 2025-04-01 14:45:47


Supplier Name	MedChemExpress (MCE)
Contact	sales
Tel	609-228-6898
Mobile	609-228-6898
QQ
Email	sales@medchemexpress.com; tech@medchemexpress.com
Website	https://www.medchemexpress.com/
Wechat

Request for quotation

Supplier Contact