Harpagoside MedChemExpress (MCE)

Product Name	Harpagosid
Synonyms	Harpagosid hapagoside HARPAGOSIDE Harpagoside HARPAGOSIDE WITH HPLC 8-O-E CINNAMOYL HARPAGIDE β-D-Glucopyranoside, (1S,4aS,5R,7S,7aS)-1,4a,5,6 Synonyms Harpagosid hapagoside HARPAGOSIDE Harpagoside HARPAGOSIDE WITH HPLC 8-O-E CINNAMOYL HARPAGIDE β-D-Glucopyranoside, (1S,4aS,5R,7S,7aS)-1,4a,5,6 7,7a-hexahydro-4a,5-dihydroxy-7-methyl-7-[[(2E)-1-oxo-3-phenyl-2-propen-1-yl]oxy]cyclopenta[c]pyran-1-yl 1-(hexopyranosyloxy)-4a,5-dihydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-7-yl 3-phenylprop-2-enoate (1S,4aS,5R,7S,7aS)-1-(beta-D-glucopyranosyloxy)-4a,5-dihydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-7-yl (2E)-3-phenylprop-2-enoate [1S-[1alpha,4aalpha,5alpha,7alpha(E),7aalpha]]-1,4a,5,6,7,7a-hexahydro-4a,5-dihydroxy-7-methyl-7-[(allyl-1-oxo-3-phenyl)oxy]cyclopenta[c]pyran-1-yl-beta-D-glucopyranoside (1S-(1alpha,4aalpha,5alpha,7alpha(E),7aalpha))-1,4a,5,6,7,7a-Hexahydro-4a,5-dihydroxy-7-methyl-7-((allyl-1-oxo-3-phenyl)oxy)cyclopenta(c)pyran-1-yl-beta-D-glucopyranoside [(1S,4aS,5R,7S,7aS)-4a,5-Dihydroxy-7-methyl-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,5,6,7a-tetrahydrocyclopenta[c]pyran-7-yl] (E)-3-phenylprop-2-enoate
CAS	19210-12-9
EINECS	242-881-6
Chemical Formula	C24H30O11
Molecular Weight	494.49
inchi	InChI=1/C24H30O11/c1-23(35-16(27)8-7-13-5-3-2-4-6-13)11-15(26)24(31)9-10-32-22(20(23)24)34-21-19(30)18(29)17(28)14(12-25)33-21/h2-10,14-15,17-22,25-26,28-31H,11-12H2,1H3/b8-7+/t14-,15-,17-,18+,19-,20-,21+,22+,23+,24-/m1/s1
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Harpagoside Harpagoside MedChemExpress (MCE) HY-N0396 19210-12-9 99.88% 4°C, protect from light In solvent : -80°C, 6 months Descriptions Harpagoside Harpagoside MedChemExpress (MCE) HY-N0396 19210-12-9 99.88% 4°C, protect from light In solvent : -80°C, 6 months -20°C, 1 month (protect from light) Room temperature in continental US may vary elsewhere. Harpagoside can be obtained by Harpagophytum procumbens, which has anti-inflammatory, anti-cancer, protective activity, and efficacy. Harpagoside has an inhibitory effect on COX-1 and COX-2 active, and suppresses NO production. Harpagoside inhibits HepG2 cell lipid polysaccharide, which is a protein that is expressed horizontally and selectively, and has anti-inflammatory and latent pain effects. Harpagoside has the ability to protect the body, and has a degenerative effect on the β-oxidation (Aβ). Harpagoside (200 μM 2 h+1 h, 6 h) inhibits lipopolysaccharide (100 ng/mL LPS)-induced mRNA levels and protein expression of cyclooxygenase 2 and inducible nitric oxide in HepG2 cells[2].Harpagoside (0.1-200 μM 4 h+1 h, 6 h) dose-dependently inhibits LPS-stimulated NF-κB promoter activity and interferes with the activation of gene transcription[2]. Harpagoside (5 mg/kg 15 mg/kg po once daily for 60 days) has potential neuroprotective effects against Aβ intoxication in an Aβ1-40-induced rat Alzheimer's disease (AD) model[3]. COX-1 COX-2 \| \| \| \| \| \| \| \| \| \| [1]. Anauate MC, et al. Effect of isolated fractions of Harpagophytum procumbens D.C. (devil's claw) on COX-1, COX-2 activity and nitric oxide production on whole-blood assay. Phytother Res. 2010 Sep 24(9):1365-9. [Content Brief] [2]. Huang TH, et al. Harpagoside suppresses lipopolysaccharide-induced iNOS and COX-2 expression through inhibition of NF-kappa B activation. J Ethnopharmacol. 2006 Mar 8 104(1-2):149-55. [Content Brief] [3]. Li J, et al. Harpagoside ameliorates the amyloid-β-induced cognitive impairment in rats via up-regulating BDNF expression and MAPK/PI3K pathways. Neuroscience. 2015 Sep 10 303:103-14. [Content Brief]
Last Update	2025-04-01 14:45:47

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