Higenamine hydrochloride MedChemExpress (MCE)

Product Name	Demethyl
Synonyms	Demethyl Higenamine HCl Norcoclaurine HCl Higenamine hydrochloride Dacacine base acid and alkali salt (+-)-Demethylcoclaurine hydrochloride 6,7-dihydroxy-1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline Synonyms Demethyl Higenamine HCl Norcoclaurine HCl Higenamine hydrochloride Dacacine base acid and alkali salt (+-)-Demethylcoclaurine hydrochloride 6,7-dihydroxy-1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline 1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline-6,7-diol hydrochloride 6,7-Dihydroxy-1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride 1,2,3,4-Tetrahydro-1-((4-hydroxyphenyl)methyl)-6,7-isoquinolinediol hydrochloride (+-)-1,2,3,4-Tetrahydro-1-((4-hydroxyphenyl)methyl)-6,7-isoquinolinediol hydrochloride 6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-((4-hydroxyphenyl)methyl)-, hydrochloride, (+-)-
CAS	11041-94-4
EINECS	1592732-453-0
Chemical Formula	C16H18ClNO3
Molecular Weight	307.77202
inchi	InChI=1/C16H17NO3.ClH/c18-12-3-1-10(2-4-12)7-14-13-9-16(20)15(19)8-11(13)5-6-17-14;/h1-4,8-9,14,17-20H,5-7H2;1H
Package	10 mM * 1 mL;100 mg;500 mg
Price	Email to quote
Descriptions	Higenamine hydrochloride Higenamine hydrochloride MedChemExpress (MCE) HY-N2037A 11041-94-4 Norcoclaurine hydrochloride 99.68% 4°C, sealed storage, away from moisture and light In solvent : -80°C, 2 years Descriptions Higenamine hydrochloride Higenamine hydrochloride MedChemExpress (MCE) HY-N2037A 11041-94-4 Norcoclaurine hydrochloride 99.68% 4°C, sealed storage, away from moisture and light In solvent : -80°C, 2 years -20°C, 1 year (sealed storage, away from moisture and light) Room temperature in continental US may vary elsewhere. Higenamine hydrochloride is a selective LSD1 inhibitor (IC50=1.47 μM) that can be isolated from aconite. Higenamine hydrochloride has anti-inflammatory and antibacterial activity. Higenamine (Norcoclaurine) can attenuate IL-1β-induced Apoptosis through ROS-mediated PI3K/Akt signaling pathway. Higenamine hydrochloride protects brain cells from oxygen deprivation. Higenamine can promote bone formation in osteoporosis through the SMAD2/3 pathway. Higenamine hydrochloride can be used to study cancer, inflammation, cardiorenal syndrome and other diseases. Higenamine hydrochloride (3-100 μM 72 h) can inhibit the differentiation of MV4-11 and MOLM-13 cells by inhibiting the activity of LSD1[1]. Higenamine hydrochloride (1-100μM 8 h) can enhance the activity of HO-1 in C6 cells and protect brain cells from cell hypoxia damage [2]. Higenamine hydrochloride (10-50 μM 8 h) can inhibit apoptosis in C6 cells[2]. Higenamine hydrochloride (10-40 μM 24 h) can inhibit the production of IL-1β-induced ROS and activate the ROS-mediated PI3K/Akt signaling pathway, which has anti-apoptotic activity in HNPCs[3]. Higenamine hydrochloride (0.08-250 μM 0.5-24 h) promotes phosphorylation of SMAD2/3 in a time- and dose-dependent manner in BMSCs[6]. Higenamine hydrochloride (10 mg/kg Intraperitoneal injection Single dose) can significantly reduce the inflammation and infarct size of cerebral ischemic injury caused by middle cerebral artery occlusion (MCAO) in Sprague-Dawley rats[2]. Higenamine hydrochloride (0.5-4.5 mg/kg Single dose) improves cardiac and renal function in rats with cardio-renal syndrome (CRS) and alleviates cardiac and renal fibrosis by targeting ASK1/MAPK (ERK, P38)/NF-kB signaling pathway in Sprague-Dawley rats[4]. Higenamine hydrochloride (20 mg/kg-30 mg/kg Intraperitoneal injection Once daily for 60 days) promotes bone formation and prevents accelerated bone loss in SAMP6 mice[6]. β adrenergic receptor ASK1 \| \| \| \| \| \| \| \| \| \| [1]. Fang Y, et al. Discovery of higenamine as a potent, selective and cellular active natural LSD1 inhibitor for MLL-rearranged leukemia therapy. Bioorg Chem. 2021 Apr 109:104723. [Content Brief] [2]. Ha YM, et al. Higenamine reduces HMGB1 during hypoxia-induced brain injury by induction of heme oxygenase-1 through PI3K/Akt/Nrf-2 signal pathways. Apoptosis. 2012 May 17(5):463-74. [Content Brief] [3]. Zhu X, et al. Higenamine mitigates interleukin-1β-induced human nucleus pulposus cell apoptosis by ROS-mediated PI3K/Akt signaling. Mol Cell Biochem. 2021 Nov 476(11):3889-3897. [Content Brief] [4]. Deng T, et al. Higenamine Improves Cardiac and Renal Fibrosis in Rats With Cardiorenal Syndrome via ASK1 Signaling Pathway. J Cardiovasc Pharmacol. 2020 Jun 75(6):535-544. [Content Brief] [5]. Erasto, Paul et al. Evaluation of Antimycobacterial Activity of Higenamine Using Galleria mellonella as an In Vivo Infection Model. Natural products and bioprospecting vol. 8,1 (2018): 63-69. [Content Brief] [6]. Dong, Hui et al. Higenamine Promotes Osteogenesis Via IQGAP1/SMAD4 Signaling Pathway and Prevents Age- and Estrogen-Dependent Bone Loss in Mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research vol. 38,5 (2023): 775-791. [Content Brief]
Last Update	2025-04-01 14:45:47

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