Hederacolchiside A1 MedChemExpress (MCE)

Product Name	Hederacolchiside A1
Synonyms	Raddeanoside R13 Hederacolchiside A1 HEDERACOLCHISIDE A1 Olean-12-en-28-oicacid, 3-[(O-6-deoxy-a-L-mannopyranosyl-(12)-O-[b-D-glucopyranosyl-(14)]-a-L-arabinopyranosyl)oxy]-, (3b)- Olean-12-en-28-oic acid, 3-[(O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-α-L-arabinopyranosyl)oxy]-, (3β)-
CAS	106577-39-3
EINECS
Chemical Formula	C47H76O16
Molecular Weight	897.1
inchi
Package	1 mg;5 mg;10 mg;25 mg;50 mg
Price	Email to quote
Descriptions	Hederacolchiside A1 Hederacolchiside A1 MedChemExpress (MCE) HY-N6950 106577-39-3 99.69% 4°C, protect from light In solvent : -80°C, 6 months Descriptions Hederacolchiside A1 Hederacolchiside A1 MedChemExpress (MCE) HY-N6950 106577-39-3 99.69% 4°C, protect from light In solvent : -80°C, 6 months -20°C, 1 month (protect from light) Room temperature in continental US may vary elsewhere. Hederacolchiside A1, isolated from Pulsatilla chinensis, suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway. Hederacolchiside A1 has antischistosomal activity, affecting parasite viability both in vivo and in vitro. Hederacolchiside A1 reduces the mitochondrial membrane potential and Bcl-2 protein levels, whereas cleaved caspase-3 was higher[1]. Hederacolchiside A1 effectively inhibits the phosphorylations of phosphatidylinositol 3 kinase (PI3K), protein kinase B (Akt), and mammalian target of rapamycin (mTOR) [1]. hederacolchiside A1 (3.0, 4.5, and 6.0 mg/kg, ip) can significantly inhibit the weight of tumor in an H22 xenograft model[1]. Hederacolchiside A1 (3.25, 7.5, and 15.0 mg/kg, ig) can significantly inhibit the weight of tumor in nude mice xenograft tumor models using human breast carcinoma MCF-7 cells[1]. Schistosome PI3K mTOR \| \| \| \| \| \| \| \| \| \| [1]. Yan-Er Wang, et al. Hederacolchiside A1 suppresses proliferation of tumor cells by inducing apoptosis through modulating PI3K/Akt/mTOR signaling pathway. Chinese Herbal Medicines.Volume 10, Issue 2, April 2018, Pages 215-222 [2]. Kang N, et al. Antischistosomal Properties of Hederacolchiside A1 Isolated from Pulsatilla chinensis. Molecules. 2018 Jun 13 23(6). [Content Brief]
Last Update	2025-04-01 14:45:47

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