Convallatoxin MedChemExpress (MCE)

Product Name	convallatoxin
Synonyms	Korglykon Corglycon Corglykon CORGLYKON HSDB 3475 NSC 407808 Corglycone Synonyms Korglykon Corglycon Corglykon CORGLYKON HSDB 3475 NSC 407808 Corglycone Convallaton CONVALLATOXIN Convallatoxin convallatoxin Convallotoxin Convallaotoxin Convallatoxine Convallatoxoside STROPHANTHIN 3ALPHA-1-RHAMNOSIDE Strophanthidin alpha-L-rhamnoside STROPHANTHIDIN A-L-RHAMNOPYRANOSIDE Rhamnoside, strophanthidin-3, alpha-L- STROPHANTHIDIN ALPHA-L-RHAMNOPYRANOSIDE Strophanthidin, 3-(6-deoxy-alpha-L-mannopyranoside) Mannopyranoside, strophanthidin-3,6-deoxy-, alpha-L- 3-[(6-deoxyhexopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide 20(22),5BETA-CARDENOLID-19-AL-3BETA,5BETA,14BETA-TRIOL-3BETA-D-[A-1-RHAMNOPYRANOSIDE] 3beta-((6-Deoxy-alpha-L-mannopyranosyl)oxy)-5,14-dihydroxy-19-oxo-5beta-card-20(22)-enolide (3beta,5beta,17xi)-3-[(6-deoxy-L-mannopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide (3beta,5beta)-3-[(6-deoxy-alpha-L-mannopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide Card-20(22)-enolide, 3-((6-deoxy-alpha-L-mannopyranosyl)oxy)-5,14-dihydroxy-19-oxo-, (3beta,5beta)- (3beta,5beta,8xi,9xi)-3-[(6-deoxy-alpha-L-mannopyranosyl)oxy]-5,14-dihydroxy-19-oxocard-20(22)-enolide Card-20(22)-enolide, 3-((6-deoxy-alpha-L-mannopyranosyl)oxy)-5,14-dihydroxy-19-oxo-, (3beta,5beta)- (9CI) Strophanthidin α-L-rhamnopyranoside, 3β,5α,14-Trihydroxy-19-oxo-5β,20(22)-cardenolide 3-(6-deoxy-α-L-mannopyranoside)
CAS	508-75-8
EINECS	208-086-3
Chemical Formula	C29H42O10
Molecular Weight	550.64
inchi	InChI=1/C29H42O10/c1-15-22(32)23(33)24(34)25(38-15)39-17-3-8-27(14-30)19-4-7-26(2)18(16-11-21(31)37-13-16)6-10-29(26,36)20(19)5-9-28(27,35)12-17/h11,14-15,17-20,22-25,32-36H,3-10,12-13H2,1-2H3/t15-,17-,18+,19?,20?,22-,23+,24+,25-,26+,27-,28-,29-/m0/s1
Package	1 mg;5 mg;10 mg
Price	Email to quote
Descriptions	Convallatoxin Convallatoxin MedChemExpress (MCE) HY-N2453 508-75-8 98.28% 4°C, protect from light In solvent : -80°C, 6 months Descriptions Convallatoxin Convallatoxin MedChemExpress (MCE) HY-N2453 508-75-8 98.28% 4°C, protect from light In solvent : -80°C, 6 months -20°C, 1 month (protect from light) Room temperature in continental US may vary elsewhere. Convallatoxin is a cardiac glycoside isolated from Adonis amurensis Regel et Radde. Convallatoxin ameliorates colitic inflammation via activation of PPARγ and suppression of NF-κB. Convallatoxin is a P-glycoprotein (P-gp) substrate and recognized Val982 as an important amino acid involved in its transport. Convallatoxin is an enhancer of ligand-induced MOR endocytosis with high potency and efficacy. Anti-inflammatory and anti-proliferative properties. Convallatoxin induces HaCaT cell necroptosis[4]. Convallatoxin exerts antipsoriatic activities in two mouse models of psoriasis[4]. \| \| \| \| \| \| \| \| \| \| [1]. Li MY, et al. Convallatoxin protects against dextran sulfate sodium-induced experimental colitis in mice by inhibiting NF-κB signaling through activation of PPARγ. Pharmacol Res. 2019 Sep 147:104355. [Content Brief] [2]. Gozalpour E, et al. Convallatoxin: a new P-glycoprotein substrate. Eur J Pharmacol. 2014 Dec 5 744:18-27. [Content Brief] [3]. Chao PK, et al. Convallatoxin enhance the ligand-induced mu-opioid receptor endocytosis and attenuate morphine antinociceptive tolerance in mice. Sci Rep. 2019 Feb 20 9(1):2405. [Content Brief] [4]. Jiang BW, et al. Convallatoxin induces HaCaT cell necroptosis and ameliorates skin lesions in psoriasis-like mouse models. Biomed Pharmacother. 2020 Jan 121:109615. [Content Brief]
Last Update	2025-04-01 14:45:47

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