Annonacin MedChemExpress (MCE)

Product Name	Annonacin
Synonyms	annonacin Annonacin ANNONACIN (5S)-5-Methyl-3-[(2R,8R,13R)-2,8,13-trihydroxy-13-[[(2R)-tetrahydro-5α-[(R)-1-hydroxytridecyl]furan]-2β-yl]tridecyl]-2(5H)-furanone 2(5H)-Furanone, 5-methyl-3-[(2R,8R,13R)-2,8,13-trihydroxy-13-[(2R,5R)-tetrahydro-5-[(1R)-1-hydroxytridecyl]-2-furanyl]tridecyl]-, (5S)-
CAS	111035-65-5
EINECS
Chemical Formula	C35H64O7
Molecular Weight	596.88
inchi
Package	1 mg
Price	Email to quote
Descriptions	Annonacin Annonacin MedChemExpress (MCE) HY-N2877 111035-65-5 97.0% 4°C, protect from light In solvent : -80°C, 6 months Descriptions Annonacin Annonacin MedChemExpress (MCE) HY-N2877 111035-65-5 97.0% 4°C, protect from light In solvent : -80°C, 6 months -20°C, 1 month (protect from light) Room temperature in continental US may vary elsewhere. Annonacin is an acetylgenin that is toxic by inhibiting the pathway of the mitochondrial complex. Annonacin increases tau phosphorylation in R406W+/+ mice. Annonacin acts as an inhibitor of the sodium/potassium and sarcoplasmic reticulum (SERCA) ATPase pumps. Annonacin has significant killing effect on ovarian cancer cell, cervical cancer cell, breast cancer cell, bladder cancer cell and skin cancer cell. Annonacin induces apoptosis through Bax and Caspase-3-related pathways. Annonacin (1-10 μg/mL 0-72 h) induces the death of a variety of cancer cell lines, and blocks cancer cells in G1 phase [2]. Annonacin 10 μg/mL 0-24 h) induces apoptosis of T24 cells and enhance the expression of pro-apoptosis-related genes [2]. Annonacin (0-9 mg/kg Subcutaneous osmotic pump 3 days) increases tau phosphorylation in R406W+/+ mice [3]. Annonacin (85 nM/100 μL Topical application Twice a week for 22 weeks) has anti-cancer effect in mouse model of skin tumor [4]. \| \| \| \| \| \| \| \| \| \| [1]. Yiallouris A, et al. Annonacin promotes selective cancer cell death via NKA-dependent and SERCA-dependent pathways. Cell Death Dis. 2018 Jul 9 9(7):764. [Content Brief] [2]. Yuan SS, et al. Annonacin, a mono-tetrahydrofuran acetogenin, arrests cancer cells at the G1 phase and causes cytotoxicity in a Bax- and caspase-3-related pathway. Life Sci. 2003 May 9 72(25):2853-61. [Content Brief] [3]. Yamada ES, et al. Annonacin, a natural lipophilic mitochondrial complex I inhibitor, increases phosphorylation of tau in the brain of FTDP-17 transgenic mice. Exp Neurol. 2014 Mar 253:113-25. [Content Brief] [4]. Md Roduan MR, et al. Modulation of cancer signalling pathway(s) in two -stage mouse skin tumorigenesis by annonacin. BMC Complement Altern Med. 2019 Sep 3 19(1):238. [Content Brief]
Last Update	2025-04-01 14:45:47

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