IsoliquiritinIsoliquiritin
MedChemExpress (MCE)
HY-N0765
5041-81-6
99.49%
4°C, protect from light *In solvent : -80°C, 6 months
-20°C, 1 month (protect from light)
Room temperature in continental US
may vary elsewhere.
Isoliquiritin, isolated from Licorice Root, inhibits angiogenesis and tube formation. Isoliquiritin also exhibits antidepressant-like, anti-oxidative, anti-Inflammatory effects and antifungal activity.
Isoliquiritin (0-400 μg/mL) inhibits the growth of a panel of plant pathogenic fungi[3]. Isoliquiritin (0-100 μg/mL, 4 h) inhibits sporangia germination of P. litchii[3]. Isoliquiritin (20 μM, 24 h) protects cell from Corticosterone (400 μM)-induced apoptosis in PC12 cells, and reduces LDH release, increases the activity of SOD, CAT, decreases the ROS and MDA level[4].
Isoliquiritin (0.31-3.1 mg/kg, i.p., once a day for 5 days) inhibits granuloma angiogenesis in mice[1]. Isoliquiritin (10-40 mg/kg, oral gavage) shows antidepressant-like effects in FST and TST tests in mice[2]. Isoliquiritin ((10 mg/kg/bw/day, p.o.) shows anti-oxidative and anti-Inflammatory properties, and relieves cationic BSA-Induced membranous glomerulonephritis in experimental rat model[5].
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[1]. Kobayashi S, et al. Inhibitory effect of isoliquiritin, a compound in licorice root, on angiogenesis in vivo and tube formation in vitro. Biol Pharm Bull. 1995 Oct
18(10):1382-6. [Content Brief]
[2]. Wang W, et al. Antidepressant-like effects of liquiritin and isoliquiritin from Glycyrrhiza uralensis in the forced swimming test and tail suspension test in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jul 1
32(5):1179-84. [Content Brief]
[3]. Luo J, et al. Antifungal Activity of Isoliquiritin and Its Inhibitory Effect against Peronophythora litchi Chen through a Membrane Damage Mechanism. Molecules. 2016 Feb 19
21(2):237. [Content Brief]
[4]. Zhou YZ, et al. Protective effect of isoliquiritin against corticosterone-induced neurotoxicity in PC12 cells. Food Funct. 2017 Mar 22
8(3):1235-1244. [Content Brief]
[5]. Liu Y, et al. Renoprotective Effects Of Isoliquiritin Against Cationic Bovine Serum Albumin-Induced Membranous Glomerulonephritis In Experimental Rat Model Through Its Anti-Oxidative And Anti-Inflammatory Properties. Drug Des Devel Ther. 2019 Oct 30
13:3735-3751. [Content Brief]