Lycorine MedChemExpress (MCE)

Product Name	Lycorine
Synonyms	Amaryline;Lycorine ;Belamarine;narcissine;amarylline;galanthidine;2-beta-diol,3,3-alpha-didehydro-lycoran-1-alph;galanthan-1,2-diol,3,12-didehydro-9,10-(methylenebis(oxy))-,(1-alpha,2-beta
CAS	476-28-8
EINECS	207-503-6
Chemical Formula	C16H17NO4
Molecular Weight	287.31
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Package	10 mM * 1 mL;50 mg;100 mg
Price	Email to quote
Descriptions	Lycorine Lycorine MedChemExpress (MCE) HY-N0288 476-28-8 99.87% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Lycorine Lycorine MedChemExpress (MCE) HY-N0288 476-28-8 99.87% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant. Lycorine is a potent and orally active SCAP inhibitor with a Kd value 15.24 nM. Lycorine downregulates the SCAP protein level without changing its transcription. Lycorine is also a melanoma vasculogenic inhibitor. Lycorine can be used for the study of prostate cancer and metabolic diseases. Lycorine inhibits cell proliferation in a dose-dependent manner in the abovementioned 4 PCa cell lines, and the IC50 ranged from 5 μM to 10 μM., it also shows Lycorine has little effects on PNT1A cell's proliferation[1].SCAP (SREBF chaperone) is an ER-toGolgi transport protein, undergoes a conformational change, and regulates/preserves SREBFs in the ER by forming a complex with INSIG1 (insulin induced gene 1)[2].Lycorine (5-40 μM 16 hours) significantly suppresses SREBFs activity (up to -70%) in a dosedependent manner and does not cause obvious cytotoxicity in cells[2].Lycorine (10-20 μM 2-16 hours) dose- and time-dependently decreases the mature SREBF1 and SREBF2 proteins in HL-7702 cells[2].Lycorine (20 μM 16 hours) neither activates NR1H3 transcription nor affect NR1H3 target genes, including ABCG5? and ABCG8, but Sterols activates NR1H3 transcription activity[1].Lycorine (0-25 μM 48 hours) treatment markedly suppresses the expression of vascular endothelial (VE)-cadherin in a dose-dependent manner and also slightly diminishes the expression of Sema4D in C8161 cells. However, the expression of the other six genes is not affected[3].Lycorine (0-25 μM 48 hours) treatment markedly reduces VE-cadherin protein levels in C8161 cells in a dose-dependent fashion[3]. Lycorine (oral chow 15 mg/kg, 30 mg/kg once daily) alleviates fat accumulation and metabolic syndrome, increases lipolysis and betaoxidation of fatty acid along with precursor and mature SREBFs in mice [2]. Kd: 15.24 nM (SCAP)[1] Cellular Effect Cell Line Type Value Description References \| \| \| \| \| \| \| \| \| \| [1]. Hu M, et al.Lycorine is a novel inhibitor of the growth and metastasis of hormone-refractory prostate cancer.Oncotarget. 2015 Jun 20 6(17):15348-61. [2]. Zu-Guo Zheng, et al. Discovery of a Potent SCAP Degrader That Ameliorates HFD-induced Obesity, Hyperlipidemia and Insulin Resistance via an Autophagy-Independent Lysosomal Pathway. Autophagy. 2020 May 20 1-22. [Content Brief] [3]. [1].Liu, R. et al. Lycorine hydrochloride inhibits metastatic melanoma cell-dominant vasculogenic mimicry. Pigment cell & melanoma research 25, 630-638, doi:10.1111/j.1755-148X.2012.01036.x (2012). [Content Brief]
Last Update	2025-04-01 14:45:47

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