Nitidine chloride MedChemExpress (MCE)

Product Name	Nitidine chloride
Synonyms	NITIDINE Angolinine Nitidine chloride NITIDINE CHLORIDE (RG) dimethoxy-12-methyl-,chloride [1,3]Dioxolo[4,5]benzo[1,2-c]phenanthridinium, 2,3- 2,3-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium Synonyms NITIDINE Angolinine Nitidine chloride NITIDINE CHLORIDE (RG) dimethoxy-12-methyl-,chloride [1,3]Dioxolo[4,5]benzo[1,2-c]phenanthridinium, 2,3- 2,3-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium 2,3-Dimethoxy-12-methyl-(1,3)-benzodioxolo(5,6-c)phenanthridinium chloride 2,3-dimethoxy-12-methyl-3,12-dihydro[1,3]benzodioxolo[5,6-c]phenanthridine 2,3-dimethoxy-12-methyl[1,3]benzodioxolo[5,6-c]phenanthridin-12-ium chloride
CAS	13063-04-2
EINECS	683-192-4
Chemical Formula	C21H18NO4+
Molecular Weight	348.37
inchi	InChI=1/C21H19NO4/c1-22-10-13-7-17(23-2)18(24-3)8-15(13)14-5-4-12-6-19-20(26-11-25-19)9-16(12)21(14)22/h4-10,18H,11H2,1-3H3
Package	1 mg;5 mg;10 mg
Price	Email to quote
Descriptions	Nitidine chloride Nitidine chloride MedChemExpress (MCE) HY-N0498 13063-04-2 99.75% 4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months Descriptions Nitidine chloride Nitidine chloride MedChemExpress (MCE) HY-N0498 13063-04-2 99.75% 4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture and light) Room temperature in continental US may vary elsewhere. Nitidine chloride, a potential anti-malarial lead compound derived from Zanthoxylum nitidum (Roxb) DC, exerts potent anticancer activity through diverse pathways, including inducing apoptosis, inhibiting STAT3 signaling cascade, DNA topoisomerase 1 and 2A, ERK and c-Src/FAK associated signaling pathway, also has anti-inflammatory activity. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kB pathway. Nitidine chloride (0-32 μM, 24-48 h) inhibits the proliferation of A498 and 768-O cells[1]. Nitidine chloride (8-16 μM, 24 h) induces apoptosis in A498 and 768-O cells[1]. Nitidine chloride (0-16 μM, 48 h) induces apoptosis in A498 cells, causes cell cycle arrest, and inhibits the ERK pathway[1]. Nitidine chloride (0-10 μM, 24 h) induces apoptosis in HSC3 and HSC4 cells, inducing apoptosis in OSCC cells through dephosphorylation of STAT3[2]. Nitidine chloride (5 mg/kg, intraperitoneal injection, once daily, 5 weeks) inhibits tumor growth in mice and induces apoptosis in renal cancer cells in vivo[1]. Nitidine chloride (0.375-10 mg/kg, intraperitoneal injection, once daily, 3 weeks) downregulates hypertrophy in mouse myocardium through AGT4B-mediated autophagy[3]. Nitidine chloride (5-10 mg/kg, intraperitoneal injection, single dose) exerts anti-inflammatory effects in endotoxin-treated mice through Akt-mediated IL-10 production[4]. Plasmodium \| \| \| \| \| \| \| \| \| \| [1]. Fang Z, et al. Nitidine chloride induces apoptosis and inhibits tumor cell proliferation via suppressing ERK signaling pathway in renal cancer. Food Chem Toxicol. 2014 Apr 66:210-6. [Content Brief] [2]. Lee-Han Kim, et al. Nitidine chloride acts as an apoptosis inducer in human oral cancer cells and a nude mouse xenograft model via inhibition of STAT3. Oncotarget. 2017 Aug 24 8(53):91306-91315. [Content Brief] [3]. Yang Hong, et al. Nitidine chloride induces cardiac hypertrophy in mice by targeting autophagy-related 4B cysteine peptidase. Acta Pharmacol Sin. 2023 Mar 44(3):561-572. [Content Brief] [4]. Niao Yang, et al. Nitidine chloride exerts anti-inflammatory action by targeting Topoisomerase I and enhancing IL-10 production. Pharmacol Res. 2019 Oct:148:104368. [Content Brief] [5]. Wang Z, et al. Nitidine chloride inhibits LPS-induced inflammatory cytokines production via MAPK and NF-kappaB pathway in RAW 264.7 cells. J Ethnopharmacol. 2012 Oct 31 144(1):145-50. [Content Brief]
Last Update	2025-04-01 14:45:47

MedChemExpress (MCE) also provides

Glycyl-L-glutamine

Category: Natural Products
CAS: 13115-71-4
Last Update: 2025-04-01 14:45:47

Triose phosphate

Category: Natural Products
CAS: 591-57-1
Last Update: 2025-04-01 14:45:47

Lactyl-CoA

Category: Natural Products
CAS: 1926-57-4
Last Update: 2025-04-01 14:45:47

12(S)-HPETE

Category: Natural Products
CAS: 71774-10-2
Last Update: 2025-04-01 14:45:47

Pyrithiamine

Category: Natural Products
CAS: 534-64-5
Last Update: 2025-04-01 14:45:47

alpha-CEHC

Category: Natural Products
CAS: 4072-32-6
Last Update: 2025-04-01 14:45:47

Maltoheptaose

Category: Natural Products
CAS: 34620-78-5
Last Update: 2025-04-01 14:45:47

Phenoxyethanol

Category: Natural Products
CAS: 122-99-6
Last Update: 2025-04-01 14:45:47


Supplier Name	MedChemExpress (MCE)
Contact	sales
Tel	609-228-6898
Mobile	609-228-6898
QQ
Email	sales@medchemexpress.com; tech@medchemexpress.com
Website	https://www.medchemexpress.com/
Wechat

Request for quotation

Supplier Contact