Sinigrin MedChemExpress (MCE)

Product Name	Sinigrin
Synonyms	Sinigrin Sinigrin Hydrate SINIGRIN, NATURAL POTASSIUM MYRONATE SINIGRIN WITH HPLC (-)-Sinigrin hydrate glucosideofallylisothiocyanate Synonyms Sinigrin Sinigrin Hydrate SINIGRIN, NATURAL POTASSIUM MYRONATE SINIGRIN WITH HPLC (-)-Sinigrin hydrate glucosideofallylisothiocyanate (-)-Sinigrin hydrate from horseradish potassium 1-(beta-D-glucopyranosylthio)but-3-enylideneaminooxysulphonate
CAS	3952-98-5
EINECS	223-545-8
Chemical Formula	C10H16KNO9S2·xH2O
Molecular Weight	397.46
inchi
Package	5 mg;10 mg;25 mg
Price	Email to quote
Descriptions	Sinigrin Sinigrin MedChemExpress (MCE) HY-N0404 3952-98-5 99.92% 4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months Descriptions Sinigrin Sinigrin MedChemExpress (MCE) HY-N0404 3952-98-5 99.92% 4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture and light) Room temperature in continental US may vary elsewhere. Sinigrin is a major glucosinolate present in plants of the Brassicaceae family. Sinigrin inhibits early-stage adipogenesis of 3T3-L1 adipocytes through the AMPK and MAPK signaling pathways. Sinigrin has potent anti-oxidant, anti-tumor and anti-inflammatory effects. Sinigrin (100 μg/mL 24 H) arrestsd cells in the G0/G1phase of the cell cycle and increased the expression of p21 and p27[1]. Sinigrin (1-100 μg/mL 8 days) remarkably inhibits the accumulation of lipid droplets and adipogenesis by downregulating the expression of C/EBPα, PPARγ, leptin and aP2. Sinigrin increases the phosphorylation of AMPK, MAPK and acetyl-CoA carboxylase (ACC) in the early stage of adipocyte differentiation, suggesting that sinigrin has anti-adipogenic effects through AMPK, MAPK and ACC activation[1]. Sinigrin (1-100 μg/mL 8 days) inhibits the production of pro-inflammatory cytokines including TNF-α and IL-6, IL-1β and IL-18[1]. Sinigrin (15-30 mg/kg Oral administration for 12 days) exerts protective and therapeutic effects on DSS‑induced colitis, by enhancing the anti-oxidant enzymes and suppressing the intestinal inflammatory cascade of markers by regulating the MAPK pathway[2]. \| \| \| \| \| \| \| \| \| \| [1]. Lee HW, et al. Inhibitory effect of sinigrin on adipocyte differentiation in 3T3-L1 cells: Involvement of AMPK and MAPK pathways. Biomed Pharmacother. 2018 Jun 102:670-680. [Content Brief] [2]. Rama Satya Sri Kotipalli, et al. Sinigrin Attenuates the Dextran Sulfate Sodium-induced Colitis in Mice by Modulating the MAPK Pathway. Inflammation. 2023 Jun 46(3):787-807. [Content Brief]
Supplier Website	https://www.medchemexpress.com/sinigrin.html
Last Update	2025-05-21 16:50:25

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