β-Aminopropionitrileβ-Aminopropionitrile
MedChemExpress (MCE)
HY-Y1750
151-18-8
BAPN
99.20%
-20°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months
-20°C, 1 month (protect from light, stored under nitrogen)
Room temperature in continental US
may vary elsewhere.
β-Aminopropionitrile (BAPN) is a specific, irreversible and orally active lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile targets the active site of LOX or LOXL isoenzymes.
β-Aminopropionitrile (BAPN) normalizes the expression of GLUT4 and adiponectin, and improves glucose uptake in an in vitro model of insulin resistance[1]. β-Aminopropionitrile (500 μM
72 h) blocks the hypoxia-induced EMT morphological and marker protein changes, and inhibits invasion and migration capacities of cervical carcinoma cells in vitro[2].
β-Aminopropionitrile (BAPN) (100 mg/kg/day
p.o.
6 weeks) reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats[1]. β-Aminopropionitrile monofumarate (1 g/kg/day
p.o.
4 weeks) induces thoracic aortic dissection in C57BL/6 mice[3].
Lysyl Oxidase Human Endogenous Metabolite
| | | |
| | | | | |
[1]. Miana M, et al. The lysyl oxidase inhibitor β-aminopropionitrile reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats. Dis Model Mech. 2015 Jun
8(6):543-51. [Content Brief]
[2]. Yang X, et al. Inactivation of lysyl oxidase by β-aminopropionitrile inhibits hypoxia-induced invasion and migration of cervical cancer cells. Oncol Rep. 2013 Feb
29(2):541-8. [Content Brief]
[3]. Ren W, et al. β-Aminopropionitrile monofumarate induces thoracic aortic dissection in C57BL/6 mice. Sci Rep. 2016 Jun 22
6:28149. [Content Brief]