Scoulerine MedChemExpress (MCE)

Product Name	Scoulerine
Synonyms	SCOULERIN Scoulerine SCOULERIN(SH) (-)-scoulerine 3,10-dimethoxy-13a-alpha-berbine-9-diol 3,10-dimethoxy-13a-alpha-berbine-2,9-diol Alkaloid HF 1, froM HunneMannia fuMariaefolia Synonyms SCOULERIN Scoulerine SCOULERIN(SH) (-)-scoulerine 3,10-dimethoxy-13a-alpha-berbine-9-diol 3,10-dimethoxy-13a-alpha-berbine-2,9-diol Alkaloid HF 1, froM HunneMannia fuMariaefolia (S)-5,8,13,13a-Tetrahydro-3,10-diMethoxy-6H-Dibenzo[a,g]quinolizine-2,9-diol (13aS)-5,8,13,13a-tTtrahydro-3,10-diMethoxy-6H-dibenzo[a,g]quinolizine-2,9-diol
CAS	6451-73-6
EINECS	200-258-5
Chemical Formula	C19H21NO4
Molecular Weight	327.37
inchi
Package	1 mg;5 mg;10 mg
Price	Email to quote
Descriptions	Scoulerine Scoulerine MedChemExpress (MCE) HY-N1255 6451-73-6 (-)-Scoulerine Descriptions Scoulerine Scoulerine MedChemExpress (MCE) HY-N1255 6451-73-6 (-)-Scoulerine Discretamine 99.27% -20°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture and light) Room temperature in continental US may vary elsewhere. Scoulerine ((-)-Scoulerine), an isoquinoline alkaloid, is a potent antimitotic compound. Scoulerine is also an inhibitor of BACE1 (?-site amyloid precursor protein cleaving enzyme 1). Scoulerine inhibits proliferation, arrests cell cycle, and induces apoptosis in cancer cells. Scoulerine ((-)-Scoulerine) inhibits mini-panel of human leukemic cells, MOLT-4 (WT), Jurkat (TP53 mutated), Raji (TP53 mutated), HL-60 (TP53 null), U-937 (TP53 mutated), and HEL 92.1.7 (wild-type), with IC50s ranging from 2.7?μM to 6.5?μM[1]. Scoulerine (2.5-20?μM 24 hours) decreases proliferation of Jurkat and MOLT-4 cells[1]. Scoulerine (2.5-20?μM 24 hours) induces MOLT-4 and Jurkat cells apoptosis[1]. Scoulerine induces G2 or M cell cycle arrest[1]. Scoulerine (2.5-5?μM 24?hours) shows an upregulation of p53 protein in p53 wild-type MOLT-4 cells[1]. Scoulerine (2.5-5?μM 24-48 hours) activates caspase-3/7, -8 and -9 in a dose-dependent manner[1]. Scoulerine (5-10 μM 24 hours) disrupts microtubule structure of A549 lung carcinoma cells[1] BACE1 \| \| \| \| \| \| \| \| \| \| [1]. Habartova K, et al. Scoulerine affects microtubule structure, inhibits proliferation, arrests cell cycle and thus culminates in the apoptotic death of cancer cells. Sci Rep. 2018 8(1):4829. Published 2018 Mar 19. [Content Brief]*
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Last Update	2025-05-21 16:50:25

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