Fmoc-Ala-Glu-Asn-Lys-NH2 MedChemExpress (MCE)

Product Name	Fmoc-Ala-Glu-Asn-Lys-NH2
Synonyms	Fmoc-Ala-Glu-Asn-Lys-NH2;L-Lysinamide, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanyl-L-α-glutamyl-L-asparaginyl- (9CI)
CAS	220701-06-4
EINECS
Chemical Formula	C33H43N7O9
Molecular Weight	681.75
inchi
Package	5 mg;10 mg
Price	Email to quote
Descriptions	Fmoc-Ala-Glu-Asn-Lys-NH2 Fmoc-Ala-Glu-Asn-Lys-NH2 MedChemExpress (MCE) HY-114174 220701-06-4 99.13% Sealed storage, away from moisture and light, under nitrogen Powder -80°C 2 years -20°C 1 year In solvent : -80°C, 6 months Descriptions Fmoc-Ala-Glu-Asn-Lys-NH2 Fmoc-Ala-Glu-Asn-Lys-NH2 MedChemExpress (MCE) HY-114174 220701-06-4 99.13% Sealed storage, away from moisture and light, under nitrogen Powder -80°C 2 years -20°C 1 year In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen) Room temperature in continental US may vary elsewhere. Fmoc-Ala-Glu-Asn-Lys-NH2 is a selective asparagine endopeptidase (AEP) inhibitor peptide and suppresses amyloid precursor protein (APP) cleavage. AEP, a pH-controlled cysteine proteinase, is activated during ageing and mediates APP proteolytic processing. Fmoc-Ala-Glu-Asn-Lys-NH2 antagonizes APP processing by AEP, whereas other small molecular inhibitors and inactive peptide AEQK were without effect[1]. \| \| \| \| \| \| \| \| \| \| [1]. Zhang Z, et al. Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease. Nat Commun. 2015 6:8762. Published 2015 Nov 9. [Content Brief] [2]. Chen G, et al. Netrin-1 receptor UNC5C cleavage by active δ-secretase enhances neurodegeneration, promoting Alzheimer's disease pathologies. Sci Adv. 2021 Apr 16 7(16):eabe4499. [Content Brief]
Last Update	2025-04-01 14:45:47

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