Demecolcine MedChemExpress (MCE)

Product Name	Decarbonylation colchicine
Synonyms	Decarbonylation colchicine
CAS	477-30-5
EINECS	207-514-6
Chemical Formula	C21H25NO5
Molecular Weight	371.43
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Demecolcine Demecolcine MedChemExpress (MCE) HY-N0282 477-30-5 99.81% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Demecolcine Demecolcine MedChemExpress (MCE) HY-N0282 477-30-5 99.81% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Demecolcine is a potent mitotic inhibitor with an IC50 value of 2.4 μM for inhibition of tubulin polymerization. Colcemid (Demecolcine) can interact with tubulin dimers to induce anti-mitotic action and inhibit microtubule growth. Colcemid (Demecolcine) can be used for inflammatory disorders and cancer research. Demecolcine (0.1-0.25 μg/ml, 1 h) reduces the the hypoploidy frequencies in metaphase II complements of mouse, rat and frog spermatocytes[3]. Demecolcine (0.3 mg/kg for intraperitoneal injection) increases the incidence of metaphase II hypoploidy in demecolcine treated mice[3]. \| \| \| \| \| \| \| \| \| \| [1]. T Tsuchida, et al. Colcemid-induced apoptosis of cultured human glioma: electron microscopic and confocal laser microscopic observation of cells sorted in different phases of cell cycle. Cytometry. 1998 Apr 1 31(4):295-9. [Content Brief] [2]. Ashley M Rozario, et al. Ultra-Low Colcemid Doses Induce Microtubule Dysfunction as Revealed by Super-Resolution Microscopy. Bioexiv. [3]. Nett RS, et al. Discovery and engineering of colchicine alkaloid biosynthesis. Nature. 2020 Aug 584(7819):148-153. doi: 10.1038/s41586-020-2546-8. Epub 2020 Jul 22. Erratum in: Nature. 2020 Jul 30. [Content Brief] [4]. Muzaffar A, et al. Antitubulin effects of derivatives of 3-demethylthiocolchicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine. Comparison with colchicinoids. J Med Chem. 1990 Feb 33(2):567-71. [Content Brief] [5]. Risley MS, et al. An improved method for cytogenetic analysis of meiotic aneuploidy in rodent and frog spermatocytes. Mutat Res. 1990 Dec 234(6):361-8. [Content Brief]
Supplier Website	https://www.medchemexpress.com/colcemid.html
Last Update	2025-05-21 16:50:25

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