2-Hydroxyestradiol MedChemExpress (MCE)

Product Name	2-Hydroxy-17β-estradiol
Synonyms	2-OH-E2α 2-HYDROXYESTRADIOL 2-Hydroxyestradiol-17α 2-Hydroxy-17β-estradiol (17β)-2-Hydroxyestradiol 2-HYDROXY 17-BETA-ESTRADIOL Estra-1(10),2,4-triene-2,3,17β-triol Synonyms 2-OH-E2α 2-HYDROXYESTRADIOL 2-Hydroxyestradiol-17α 2-Hydroxy-17β-estradiol (17β)-2-Hydroxyestradiol 2-HYDROXY 17-BETA-ESTRADIOL Estra-1(10),2,4-triene-2,3,17β-triol estra-1,3,5(10)-triene-2,3,17-beta-triol 1,3,5(10)-Estratriene-2,3-17β-triol, Estra-1,3,5(10)-triene-2,3,17-triol
CAS	362-05-0
EINECS
Chemical Formula	C18H24O3
Molecular Weight	288.38
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg
Price	Email to quote
Descriptions	2-Hydroxyestradiol 2-Hydroxyestradiol MedChemExpress (MCE) HY-124489 362-05-0 97.0% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions 2-Hydroxyestradiol 2-Hydroxyestradiol MedChemExpress (MCE) HY-124489 362-05-0 97.0% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. 2-Hydroxyestradiol, a metabolite of 17β-estradiol with minimal estrogenic activity, possesses antioxidant effects and reacts with DNA to form stable adducts and exerts genotoxicity. 2-Hydroxyestradiol induces phenotypical changes indicative of neoplastic transformation[1]. 2-Hydroxyestradiol (2-OHE2) is capable of in vitro transforming a HBEC, MCF-10F cell line, that is estrogen receptor-a (ERα) negative and ERβ positive[1]. 2-Hydroxyestradiol induces oxidative DNA damage and apoptosis in human mammary epithelial cells[3]. 2-Hydroxyestradiol attenuated the development of obesity and improved endothelial function, decreased nephropathy, decreased the severity of diabetes, lowered arterial blood pressure, and reduced plasma cholesterol[2]. Human Endogenous Metabolite \| \| \| \| \| \| \| \| \| \| [1]. C H Van Aswegen, et al. Binding of 2-hydroxyestradiol and 4-hydroxyestradiol to estrogen receptors from human breast cancers. J Steroid Biochem. 1989 Apr 32(4):485-92. [Content Brief] [2]. S P Tofovic, et al. 2-Hydroxyestradiol attenuates the development of obesity, the metabolic syndrome, and vascular and renal dysfunction in obese ZSF1 rats. J Pharmacol Exp Ther. 2001 Dec 299(3):973-7. [Content Brief] [3]. Yeon-Jin Hurh, et al. 2-Hydroxyestradiol induces oxidative DNA damage and apoptosis in human mammary epithelial cells. J Toxicol Environ Health A. 2004 Dec 67(23-24):1939-53. [Content Brief]
Last Update	2025-04-01 14:45:47

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