Dehydroglyasperin C MedChemExpress (MCE)

Product Name	Dehydroglyasperin C
Synonyms	Dehydroglyasperin C;4-[7-Hydroxy-5-methoxy-6-(3-methyl-2-butenyl)-2H-1-benzopyran-3-yl]-1,3-benzenediol;1,3-Benzenediol, 4-[7-hydroxy-5-methoxy-6-(3-methyl-2-buten-1-yl)-2H-1-benzopyran-3-yl]-
CAS	199331-35-6
EINECS
Chemical Formula	C21H22O5
Molecular Weight	354.39638
inchi
Package	1 mg
Price	Email to quote
Descriptions	Dehydroglyasperin C Dehydroglyasperin C MedChemExpress (MCE) HY-N7335 199331-35-6 99.12% 4°C, protect from light In solvent : -80°C, 6 months Descriptions Dehydroglyasperin C Dehydroglyasperin C MedChemExpress (MCE) HY-N7335 199331-35-6 99.12% 4°C, protect from light In solvent : -80°C, 6 months -20°C, 1 month (protect from light) Room temperature in continental US may vary elsewhere. Dehydroglyasperin C, a isoflavone, is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C has antioxidant, neuroprotective, cancer chemopreventive, and anti-inflammatory activities. Dehydroglyasperin C (0.1-1 μM 24 h) blocks the PDGF-induced progression through the G0/G1 to S phase of the cell cycle, and down-regulates the expression of CDK 2, cyclin E, CDK4 and cyclin D1. Dehydroglyasperin C significantly attenuates PDGF-stimulated phosphorylation of PDGF receptor-β, phospholipase C-γ1, AKT and extracellular-regulated kinase 1/2, and DGC inhibits cell migration and the dissociation of actin filaments by PDGF[1]. Dehydroglyasperin C (0.1-1 μM 24 h) treatment significantly decreases PDGF-induced cell number and DNA synthesis in a dose-dependent manner without any cytotoxicity in human aortic smooth muscle cells (HASMC)[1]. In ICR mice, Dehydroglyasperin C (5 mg/kg once) combined with CCl4 shows reduced lipid droplet formation in liver tissue, as assessed by histological examination. Further, DGC demonstrated a slight protective effect against centrilobular injury caused by CCl4 injection, perhaps through suppression of CYP2E1 expression[4]. \| \| \| \| \| \| \| \| \| \| [1]. Hyo Jung Kim, et al. Dehydroglyasperin C, a component of liquorice, attenuates proliferation and migration induced by platelet-derived growth factor in human arterial smooth muscle cells. Br J Nutr. 2013 Aug 28 110(3):391-400. [Content Brief] [2]. Ji Hoon Lee, et al. Dehydroglyasperin C suppresses TPA-induced cell transformation through direct inhibition of MKK4 and PI3K. Mol Carcinog. 2016 May 55(5):552-62. [Content Brief] [3]. Ji Yeon Seo, et al. Dehydroglyasperin C isolated from licorice caused Nrf2-mediated induction of detoxifying enzymes. J Agric Food Chem. 2010 Feb 10 58(3):1603-8. [Content Brief] [4]. Seo, J.Y, et al. Protective effects of dehydroglyasperin c against carbon tetrachloride-induced liver damage in mice. Food Sci Biotechnol 23, 547–553 (2014).
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Last Update	2025-05-21 16:50:25

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