2-Hydroxyestrone MedChemExpress (MCE)

Product Name	2-Hydroxy Estrone
Synonyms	2-HYDROXYESTRONE 2-Hydroxy Estrone 2,3-Dihydroxy-1(10),2,4-est 1,3,5(10)Estatrien-2,3-diol-17-one 1,3,5(10)-ESTRATRIEN-2,3-DIOL-17-ONE 1,3,5[10]-ESTRATRIENE-2,3-DIOL-17-ONE 2,3-DIHYDROXY-1,3,5[10]-ESTRATRIEN-17-ONE Synonyms 2-HYDROXYESTRONE 2-Hydroxy Estrone 2,3-Dihydroxy-1(10),2,4-est 1,3,5(10)Estatrien-2,3-diol-17-one 1,3,5(10)-ESTRATRIEN-2,3-DIOL-17-ONE 1,3,5[10]-ESTRATRIENE-2,3-DIOL-17-ONE 2,3-DIHYDROXY-1,3,5[10]-ESTRATRIEN-17-ONE 2,3-dihydroxy-estra-1,3,5(10)-trien-17-one 2,3-Dihydroxy-1(10),2,4-estratriene-17-one
CAS	362-06-1
EINECS
Chemical Formula	C18H22O3
Molecular Weight	286.37
inchi
Package	1 mg
Price	Email to quote
Descriptions	2-Hydroxyestrone 2-Hydroxyestrone MedChemExpress (MCE) HY-113251 362-06-1 Catecholestrone 98.57% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions 2-Hydroxyestrone 2-Hydroxyestrone MedChemExpress (MCE) HY-113251 362-06-1 Catecholestrone 98.57% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. 2-Hydroxyestrone (Catecholestrone) is a specific receptor-mediated antiestrogenic agent. 2-Hydroxyestrone is anticarcinogenic. 2-Hydroxyestrone exhibits antiestrogen action on MCF-7 human breast cancer cells. Addition of 2-Hydroxyestrone to the cell cultures in concentration of 1-1000 nM has no effect on cell growth and proliferation because of rapid O-methylation of the catechol estrogen by catechol O-methyltransferase which is highly active in these cells. In the presence of quinalizarin, a potent catechol O-methyltransferase inhibitor which reduces the O-methylation of the steroid, 10 and 100 nM 2-Hydroxyestrone markedly suppresses the growth and proliferation of the cells[2]. Levels of both 2-Hydroxyestrone (2-OHE1 2 mg/kg administered ip.) and 2-Hydroxyestrone 4-N-acetylcysteine thioether (2-OHE1 4SR) in rats treated with 2-Hydroxyestrone were significantly different between the induced and noninduced groups[3]. Human Endogenous Metabolite Estrogen receptor \| \| \| \| \| \| \| \| \| \| [1]. H L Bradlow, et al. 2-Hydroxyestrone: the 'good' estrogen. J Endocrinol. 1996 Sep 150 Suppl:S259-65. [Content Brief] [2]. J Schneider, et al. Antiestrogen action of 2-Hydroxyestrone on MCF-7 human breast cancer cells. J Biol Chem. 1984 Apr 25 259(8):4840-5. [Content Brief] [3]. M Nakagomi, et al. Quantitation of catechol estrogens and their N-acetylcysteine conjugates in urine of rats and hamsters. Chem Res Toxicol. 2000 Dec 13(12):1208-13. [Content Brief]
Supplier Website	https://www.medchemexpress.com/2-hydroxyestrone.html
Last Update	2025-05-21 16:50:25

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