C12-200 MedChemExpress (MCE)

Product Name	C12-200
Synonyms	C12-200 1,1'-((2-(4-(2-((2-(BIS(2-HYDROXYDODECYL)AMINO)ETHYL)(2-HYDROXYDODECYL)AMINO)ETHYL)PIPERAZIN-1-YL)ET 1-[2-[Bis(2-hydroxydodecyl)amino]ethyl-[2-[4-[2-[bis(2-hydroxydodecyl)amino]ethyl]piperazin-1-yl]ethyl]amino]dodecan-2-ol Synonyms C12-200 1,1'-((2-(4-(2-((2-(BIS(2-HYDROXYDODECYL)AMINO)ETHYL)(2-HYDROXYDODECYL)AMINO)ETHYL)PIPERAZIN-1-YL)ET 1-[2-[Bis(2-hydroxydodecyl)amino]ethyl-[2-[4-[2-[bis(2-hydroxydodecyl)amino]ethyl]piperazin-1-yl]ethyl]amino]dodecan-2-ol 2-Dodecanol, 1,1'-[[2-[4-[2-[[2-[bis(2-hydroxydodecyl)amino]ethyl](2-hydroxydodecyl)amino]ethyl]-1-piperazinyl]ethyl]imino]bis- 1,1'-((2-(4-(2-((2-(bis(2-hydroxydodecyl)amino)ethyl)(2-hydroxydodecyl)amino)ethyl)piperazin-1-yl)ethyl)azanediyl)bis(dodecan-2-ol)
CAS	1220890-25-4
EINECS
Chemical Formula	C70H145N5O5
Molecular Weight	1136.93
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg
Price	Email to quote
Descriptions	C12-200 C12-200 MedChemExpress (MCE) HY-145405 1220890-25-4 99.91% Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions C12-200 C12-200 MedChemExpress (MCE) HY-145405 1220890-25-4 99.91% Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. C12-200 is a type of ionizable cationic lipid and helper lipid commonly used for mRNA delivery. In the hemophilia B mouse model, mRNA encoding human erythropoietin (EPO) and coagulation factor IX (FIX) can be successfully delivered and expressed using C12-200. C12-200 is utilized in research related to hemophilia B. C12-200 (0.25 or 0.5 mg/kg, i.v., single injection) delivers exogenous human mRNA, producing target proteins at supraphysiological levels. Human erythropoietin (EPO) and coagulation factor IX (FIX) demonstrate potent pharmacodynamic effects in the KO mouse model[2]. \| \| \| \| \| \| \| \| \| \| [1]. Khare P, et al. Development of Lipidoid Nanoparticles for siRNA Delivery to Neural Cells. AAPS J. 2021 24(1):8. Published 2021 Dec 6. [Content Brief] [2]. DeRosa F, et al. Therapeutic efficacy in a hemophilia B model using a biosynthetic mRNA liver depot system. Gene Ther. 2016 23(10):699-707. [Content Brief] [3]. Kauffman KJ, et al. Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs. Nano Lett. 2015 Nov 11 15(11):7300-6. [Content Brief]
Last Update	2025-04-01 14:45:47

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