Ompenaclid MedChemExpress (MCE)

Product Name	Guanidine propionate
Synonyms	Guanidine propionate guanidinopropionicacid guanidinepropanoicacid 3-guanidinopropanoicacid 3-guanidinopropionic acid beta-guanidinopropionic acid n-(aminoiminomethyl)-beta-alanin Synonyms Guanidine propionate guanidinopropionicacid guanidinepropanoicacid 3-guanidinopropanoicacid 3-guanidinopropionic acid beta-guanidinopropionic acid n-(aminoiminomethyl)-beta-alanin n-(aminoiminomethyl)beta-alanine b-Alanine, N-(aMinoiMinoMethyl)- N-(diaminomethylidene)-beta-alanine 3-(diaminomethylideneamino)propanoic acid 3-[bis(azanyl)methylideneamino]propanoic acid
CAS	353-09-3
EINECS	206-530-0
Chemical Formula	C4H9N3O2
Molecular Weight	131.13
inchi	InChI=1/C4H9N3O2/c5-4(6)7-2-1-3(8)9/h1-2H2,(H,8,9)(H4,5,6,7)
Package	10 mM * 1 mL;50 mg;100 mg
Price	Email to quote
Descriptions	Ompenaclid Ompenaclid MedChemExpress (MCE) HY-W015828 353-09-3 RGX-202 Descriptions Ompenaclid Ompenaclid MedChemExpress (MCE) HY-W015828 353-09-3 RGX-202 3-Guanidinopropionic acid 98.0% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Ompenaclid (RGX-202) is an oral small-molecule SLC6A8 transporter inhibitor. Ompenaclid robustly inhibits creatine import in vitro and in vivo, reduces intracellular phosphocreatine and ATP levels, and induces tumor apoptosis. Ompenaclid can be used for the research of cancer and duchenne muscular dystrophy. Ompenaclid (RGX-202 10 μM 96 hours) reduces cell growth, and reveals a nearly complete depletion of phosphocreatine (>99%), greater than 79% reduction in cellular creatine and a substantial (46%) reduction in intracellular ATP levels relative to control cells in hypoxia[1]. Ompenaclid (RGX-202 800 mg/kg p.o. for 35 days) reduces UN-KPC-961 pancreatic tumoral creatine levels in B6129SF1/J mice[1].?Ompenaclid (approximately 650 mg/kg i.p. daily for 14 days) treatment reduces Lvm3b cells liver metastatic colonization by eightfold in NOD-SCID mice[1]. Human Endogenous Metabolite \| \| \| \| \| \| \| \| \| \| [1]. Kurth I, et al. Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels. Sci Adv. 2021 Oct 8 7(41):eabi7511. [Content Brief] [2]. Creisméas A, et, al. TRPC1 and TRPC3 involvement in DMD physiopathology and as potential targets for treatment in complement to rAAV-microdystrophin. 2021 Oct 1 13.
Supplier Website	https://www.medchemexpress.com/ompenaclid.html
Last Update	2025-05-21 16:50:25

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