PSI MedChemExpress (MCE)

Product Name	PROTEASOME INHIBITOR I
Synonyms	PSI Z-IE(OTBU)AL-CHO PROTEASOME INHIBITOR I PROTEASOME INHIBITOR PSI PROTEASOME INHIBITOR I (ALDEHYDE) N-CBZ-ILE-GLU(O-T-BUTYL)-ALA-LEUCINAL CARBOBENZOXY-L-ISOLEUCYL-GAMMA-T-BUTYL-L-GLUTAMYL-L-ALANYL-L-LEUCINAL Synonyms PSI Z-IE(OTBU)AL-CHO PROTEASOME INHIBITOR I PROTEASOME INHIBITOR PSI PROTEASOME INHIBITOR I (ALDEHYDE) N-CBZ-ILE-GLU(O-T-BUTYL)-ALA-LEUCINAL CARBOBENZOXY-L-ISOLEUCYL-GAMMA-T-BUTYL-L-GLUTAMYL-L-ALANYL-L-LEUCINAL BENZYLOXYCARBONYL-L-ISOLEUCYL-[(2S)-2-AMINO-4-(T-BUTYLOXYCARBONYL)BUTANOYL]-L-ALANYL-L-LEUCINAL
CAS	158442-41-2
EINECS
Chemical Formula	C32H50N4O8
Molecular Weight	618.76
inchi
Package	1 mg;5 mg;10 mg
Price	Email to quote
Descriptions	PSI PSI MedChemExpress (MCE) HY-P1258 158442-41-2 Proteasome Inhibitor 1 Descriptions PSI PSI MedChemExpress (MCE) HY-P1258 158442-41-2 Proteasome Inhibitor 1 Z-Ile-Glu(OtBu)-Ala-Leu-CHO 97.0% Sealed storage, away from moisture Powder -80°C 2 years -20°C 1 year In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. PSI (Proteasome Inhibitor 1) is a potent proteasome inhibitor. PSI inhibits the proliferation of primary effusion lymphoma (PEL) cells. PSI has the potential for the research of Kaposi’s sarcoma-associated herpesvirus (KSHV) infection and KSHV-associated lymphomas. PSI (24 h) inhibits the proliferation of primary effusion lymphoma (PEL) cells at low nanomolar concentrations (CC50s of 205, 190, 22.0, 53.0 nM FOR BJAB, Ramos, BC3, BCBL1 cells, respectively)[1]. PSI (50 nM 6 h) increases caspase-3/7 activity by 8-fold compared with control[1]. PSI (50 nM 6 h) decreases the transcriptional activity of NF-κB by 52%[1]. PSI (1, 5 nM 3 days) inhibits the growth of BC3 cells at a high concentration (5 nM)[1]. \| \| \| \| \| \| \| \| \| \| [1]. Saji C, et al. Proteasome inhibitors induce apoptosis and reduce viral replication in primary effusion lymphoma cells. Biochem Biophys Res Commun. 2011 415(4):573-8. [Content Brief]*
Last Update	2025-04-01 14:45:47

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