Felodipine-d5 MedChemExpress (MCE)

Product Name	felodipine-d5
Synonyms	felodipine-d5;rac Felodipine (Ethoxy-d5)
CAS	1242281-38-4
EINECS
Chemical Formula	C18H19Cl2NO4
Molecular Weight	384.25
inchi
Package	5 mg;1 mg
Price	Email to quote
Descriptions	Felodipine-d5 Felodipine-d5 MedChemExpress (MCE) HY-B0309S1 1242281-38-4 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions Felodipine-d5 Felodipine-d5 MedChemExpress (MCE) HY-B0309S1 1242281-38-4 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Felodipine-d5 is deuterium labeled Felodipine. Felodipine, a dihydropyridine, is a potent, vasoselective calcium channel antagonist. Felodipine lowers blood pressure (BP) by selective action on vascular smooth muscle, especially in the resistance vessels. Felodipine, an anti-hypertensive agent, induces autophagy. Felodipine can cross the blood-brain barrier[1][2][3]. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. \| \| \| \| \| \| \| \| \| \| [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 53(2):211-216. [Content Brief] [2]. Johnson JD, et al. Calcium and calmodulin antagonists binding to calmodulin and relaxation of coronary segments. J Pharmacol Exp Ther. 1983 226(2):330-334. [Content Brief] [3]. Siddiqi FH, et al. Felodipine induces autophagy in mouse brains with pharmacokinetics amenable to repurposing [published correction appears in Nat Commun. 2019 Jun 4 10(1):2530]. Nat Commun. 2019 10(1):1817. Published 2019 Apr 18. [Content Brief] [4]. Yiu, S. and E.E. Knaus, Synthesis, biological evaluation, calcium channel antagonist activity, and anticonvulsant activity of felodipine coupled to a dihydropyridine-pyridinium salt redox chemical delivery system. J Med Chem, 1996. 39(23): p. 4576-82. [Content Brief]
Supplier Website	https://www.medchemexpress.com/felodipine-d5.html
Last Update	2025-05-21 16:50:25

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