Flufenamic acid-d4 MedChemExpress (MCE)

Product Name	LPEPZBJOKDYZAD-ZEJCXXMWSA-N
Synonyms	FLUFENAMIC ACID-D4;LPEPZBJOKDYZAD-ZEJCXXMWSA-N
CAS	1185071-99-1
EINECS
Chemical Formula	C14H6D4F3NO2
Molecular Weight	285.254556712
inchi
Package	1 mg;5 mg;500 μg
Price	Email to quote
Descriptions	Flufenamic acid-d4 Flufenamic acid-d4 MedChemExpress (MCE) HY-B1221S 1185071-99-1 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions Flufenamic acid-d4 Flufenamic acid-d4 MedChemExpress (MCE) HY-B1221S 1185071-99-1 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Flufenamic acid-d4 is deuterium labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca2+ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation. \| \| \| \| \| \| \| \| \| \| [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 53(2):211-216. [Content Brief] [2]. Guinamard R, et al. Flufenamic acid as an ion channel modulator. Pharmacol Ther. 2013 May 138(2):272-84. [Content Brief] [3]. Pongkorpsakol P, et al. Flufenamic acid protects against intestinal fluid secretion and barrier leakage in a mouse model of Vibrio cholerae infection through NF-κB inhibition and AMPK activation. Eur J Pharmacol. 2017 Mar 5 798:94-104. [Content Brief] [4]. Pongkorpsakol P, et al. Cellular mechanisms underlying the inhibitory effect of flufenamic acid on chloride secretion in human intestinal epithelial cells. J Pharmacol Sci. 2017 Jun 134(2):93-100. [Content Brief] [5]. Pobbati AV, et al. Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy. Structure. 2015 23(11):2076-2086. [Content Brief]
Last Update	2025-04-01 14:45:47

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