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  6. Closantel-13C6

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Supplier NameMedChemExpress (MCE)
Contactsales
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Emailsales@medchemexpress.com; tech@medchemexpress.com
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Product NameClosantel-13C6
Synonyms13C6-Closantel;Closantel-13C6;[13C6]-CLOSANTEL;Closantel-(benzoyl ring-13C6);N-{5-Chloro-4-[(4-chlorophenyl)cyanomethyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide-13C6
CAS1325559-20-3
EINECS
Chemical FormulaC1613C6H14Cl2I2N2O2
Molecular Weight
inchi
Package1 mg;5 mg
PriceEmail to quote
DescriptionsClosantel-13C6

Closantel-13C6

MedChemExpress (MCE)

HY-17596S

1325559-20-3

Please store the product under the recommended conditions in the Certificate of Analysis.

Room temperature in continental US

Descriptions

Closantel-13C6

Closantel-13C6

MedChemExpress (MCE)

HY-17596S

1325559-20-3

Please store the product under the recommended conditions in the Certificate of Analysis.

Room temperature in continental US
may vary elsewhere.

Closantel-13C6 is the 13C6 labeled Closantel. Closantel is a halogenated salicylanilide with a potent anti-parasitic activity. Closantel is a potent and highly specific Onchocerca volvulus chitinase (OvCHT1) inhibitor with an IC50 of 1.6 μM and a Ki of 468 nM. Closantel inhibits the O. volvulus L3 to L4 molt of developing.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

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[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb
53(2):211-216. [Content Brief]

[2]. Amanda L Garner, et al. Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus. J Med Chem. 2011 Jun 9
54(11):3963-72. [Content Brief]

[3]. Amanda L Garner, et al. Design, synthesis, and biological activities of closantel analogues: structural promiscuity and its impact on Onchocerca volvulus. J Med Chem. 2011 Jun 9
54(11):3963-72. [Content Brief]

Last Update2025-04-01 14:45:47
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