Homobutein MedChemExpress (MCE)

Product Name	HOMOBUTEIN
Synonyms	HOMOBUTEIN HOMOBUTEIN hplc Einecs 251-782-7 3-O-methylbutein HOMOBUTEIN WITH HPLC 4,2',4'-Trihydroxy-3-methoxychalcone (E)-2',4,4'-trihydroxy-3-methoxychalcone Synonyms HOMOBUTEIN HOMOBUTEIN hplc Einecs 251-782-7 3-O-methylbutein HOMOBUTEIN WITH HPLC 4,2',4'-Trihydroxy-3-methoxychalcone (E)-2',4,4'-trihydroxy-3-methoxychalcone (E)-1-(2,4-Dihydroxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-2-propen-1-one
CAS	34000-39-0
EINECS	251-782-7
Chemical Formula	C16H14O5
Molecular Weight	286.28
inchi
Package	1 mg;5 mg
Price	Email to quote
Descriptions	Homobutein Homobutein MedChemExpress (MCE) HY-N8707 34000-39-0 98.35% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Homobutein Homobutein MedChemExpress (MCE) HY-N8707 34000-39-0 98.35% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Homobutein a natural chalcones (can be found in many medicinal plants, fruits, vegetables, spices and nuts), is a potent HDACs/NF-κB dual inhibitor with IC50s of 190 and 38 μM, respectively. Homobutein also a chelator of iron (II and III) cations, shows various activities, including anticancer, anti-inflammatory, antiparasite and antioxidation. Homobutein (compound 15) (20, 24, 28, 32, 40 μM 2 h) inhibits the viability of K562 cells[1]. Homobutein (2 h) inhibits TNFα-induced NF-κB activity in K562 cells[1]. Homobutein (1 μg/mL 72 h) inhibits the growth of Toxoplasma gondii by 19.48%[2]. Homobutein (24 h) againsts W2 and D6 strains of P.falciparum with IC50s of 15.0 and 16.1 μM, respectively[3]. Toxoplasma \| \| \| \| \| \| \| \| \| \| [1]. Orlikova B, et al. Natural chalcones as dual inhibitors of HDACs and NF-κB. Oncol Rep. 2012 Sep 28(3):797-805. [Content Brief] [2]. Adeyemi OS, et al. In Vitro Screening to Identify Anti-Toxoplasma Compounds and In Silico Modeling for Bioactivities and Toxicity. Yale J Biol Med. 2019 Sep 20 92(3):369-383. [Content Brief] [3]. Yenesew A, et al. Anti-plasmodial flavonoids from the stem bark of Erythrina abyssinica. Phytochemistry. 2004 Nov 65(22):3029-32. [Content Brief] [4]. Serobatse K, et al. Antioxidant and antimalarial properties of butein and homobutein based on their ability to chelate iron (II and III) cations: a DFT study in vacuo and in solution. European Food Research and Technology, 2016, 242(1): 71-90.
Last Update	2025-04-01 14:45:47

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