PGLa MedChemExpress (MCE)

Product Name	PGLa
Synonyms	PGLA PGLa MSI 499 peptide-Gly-Leu-amide PGLa ion channel-forming peptide Gly-Met-Ala-Ser-Lys-Ala-Gly-Ala-Ile-Ala-Gly-Lys-Ile-Ala-Lys-Val-Ala-Leu-Lys-Ala-Leu-NH2 H-GLY-MET-ALA-SER-LYS-ALA-GLY-ALA-ILE-ALA-GLY-LYS-ILE-ALA-LYS-VAL-ALA-LEU-LYS-ALA-LEU-NH2 Synonyms PGLA PGLa MSI 499 peptide-Gly-Leu-amide PGLa ion channel-forming peptide Gly-Met-Ala-Ser-Lys-Ala-Gly-Ala-Ile-Ala-Gly-Lys-Ile-Ala-Lys-Val-Ala-Leu-Lys-Ala-Leu-NH2 H-GLY-MET-ALA-SER-LYS-ALA-GLY-ALA-ILE-ALA-GLY-LYS-ILE-ALA-LYS-VAL-ALA-LEU-LYS-ALA-LEU-NH2 L-Leucinamide,glycyl-L-methionyl-L-alanyl-L-seryl-L-lysyl-L-alanylglycyl-L-alanyl-L-isoleucyl-L-alanylglycyl-L-lysyl-L-isoleucyl-L-alanyl-L-lysyl-L-valyl-L-alanyl-L-leucyl-L-lysyl-L-alanyl-
CAS	102068-15-5
EINECS
Chemical Formula	C88H162N26O22S
Molecular Weight	1968.45
inchi
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Descriptions	PGLa PGLa MedChemExpress (MCE) HY-P0274 102068-15-5 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions PGLa PGLa MedChemExpress (MCE) HY-P0274 102068-15-5 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. PGLa, a 21-residue peptide, is an antimicrobial peptide. PGLa is a member of the magainin family of antibiotic peptides found in frog skin and its secretions. PGLa is a peptide starting with a glycine and ending with a leucine amide[1]. PGLa is bacteriostatic against both Gram-positive and Gram-negative bacteria with MIC values of 64 and 32 mg/L against S. aureus and E. coli, respectively[2]. Anti-bacteria[1] Cellular Effect Cell Line Type Value Description References Gly-Met-Ala-Ser-Lys-Ala-Gly-Ala-Ile-Ala-Gly-Lys-Ile-Ala-Lys-Val-Ala-Leu-Lys-Ala-Leu-NH2 \| \| \| \| \| \| \| \| \| \| [1]. Bechinger B, et al. Structure and dynamics of the antibiotic peptide PGLa in membranes by solution and solid-state nuclear magnetic resonance spectroscopy. Biophys J. 1998 Feb 74(2 Pt 1):981-7. [Content Brief] [2]. Radchenko DS, et al. Does a methionine-to-norleucine substitution in PGLa influence peptide-membrane interactions? Biochim Biophys Acta. 2016 Sep 1858(9):2019-27. [Content Brief]
Last Update	2025-04-01 14:45:47

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