β-Amyloid (22-35) MedChemExpress (MCE)

Product Name	H-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-OH
Synonyms	EDVGSNKGAIIGLM BETA-AMYLOID (22-35) AMYLOID BETA-PROTEIN (22-35) AMYLOID B-PROTEIN FRAGMENT 22-35 AMYLOID Β-PROTEIN FRAGMENT 22-35 amyloid β-protein fragment 22-35 AMYLOID BETA-PROTEIN FRAGMENT 22-35 Synonyms EDVGSNKGAIIGLM BETA-AMYLOID (22-35) AMYLOID BETA-PROTEIN (22-35) AMYLOID B-PROTEIN FRAGMENT 22-35 AMYLOID Β-PROTEIN FRAGMENT 22-35 amyloid β-protein fragment 22-35 AMYLOID BETA-PROTEIN FRAGMENT 22-35 GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET H-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-OH
CAS	144189-71-9
EINECS
Chemical Formula	C59H102N16O21S
Molecular Weight	1403.6
inchi
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Descriptions	β-Amyloid (22-35) β-Amyloid (22-35) MedChemExpress (MCE) HY-P1474 144189-71-9 Amyloid β-Protein (22-35) Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions β-Amyloid (22-35) β-Amyloid (22-35) MedChemExpress (MCE) HY-P1474 144189-71-9 Amyloid β-Protein (22-35) Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. β-Amyloid 22-35 (Amyloid β-Protein 22-35), the residues 22-35 fragment ofβ-amyloid protein, has a cytotoxic effect on cultured neurons from the rat hippocampus in serum-free medium. β-Amyloid 22-35 forms aggregates and typical amyloid fibrils resembling those of the β-amyloid protein in neutral buffer solution). β-Amyloid 22-35 shows significant cytotoxicity on the rat hippocampal neurons at 40 μg/mL, but exhibits no cytotoxic effect on the glial cells[1]. Hippocampal cells are cultured in DMEM supplemented with 10% (v/v) precolostrum newborn calf serum in poly-D-lysine-coated 24-well culture plates at 37°C under a gas mixture of 95% air/5% CO2. After 6 days of culture, non-neuronal cell division is halted by 24 h exposure to 10-5 cytosine arabinoside. After washing cell layers with DMEM, cells are cultured with 1 mL of DMEM per well in the absence of serum for 5 days before experiment. Cells are treated for 3 days with β-Amyloid (22-35) or its amidated (C-terminus) derivative by addition of 20 μL of stock solution (2 mg/mL of either in betaine buffer, pH 8.5, consisting of 0.7% betaine and 20 mM NH4HCO3) to 1.0 mL medium, unless otherwise specified. Control cells are treated with the betaine buffer alone. Morphological change of cells is checked throughout the course of experiment with a phase-contrast microscope. Dead cells are checked by trypan blue staining. Cell injury is assessed by measuring lactate dehydrogenase (LDH) activity released into medium during 3 days of treatment of neurons with peptides[1]. Amyloid-β[1] In Vitro β-Amyloid 22-35 shows significant cytotoxicity on the rat hippocampal neurons at 40 μg/mL, but exhibits no cytotoxic effect on the glial cells[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> β-Amyloid (22-35) Related Antibodies Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met \| \| \| \| \| \| \| \| \| \| [1]. Takadera T, et al. Toxic effect of a beta-amyloid peptide (beta 22-35) on the hippocampal neuron and its prevention. Neurosci Lett. 1993 Oct 14 161(1):41-4. [Content Brief] [2]. Zhou WW, et al. Decreasing oxidative stress and neuroinflammation with a multifunctional peptide rescues memory deficits in mice with Alzheimer disease. Free Radic Biol Med. 2014 74:50-63. [Content Brief]
Last Update	2025-04-01 14:45:47

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