BW-180C MedChemExpress (MCE)

Product Name	H-TYR-D-ALA-GLY-PHE-D-LEU-OH
Synonyms	YAGFL;DADLE;TYR-D-ALA-GLY-PHE-D-LEU;(D-ALA2,D-LEU5)-ENKEPHALIN;H-TYR-D-ALA-GLY-PHE-D-LEU-OH;Enkephalin, Leucine-2-Alanine;TYR-D-ALA-GLY-PHE-D-LEU ACOH H2O;[D-ALA2,D-LEU5]-ENKEPHALIN ACOH H2O
CAS	63631-40-3
EINECS
Chemical Formula	C29H39N5O7
Molecular Weight	569.65
inchi
Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Get quote
Descriptions	BW-180C BW-180C MedChemExpress (MCE) HY-105343 63631-40-3 [D-Ala2, D-Leu5]-Enkephalin Descriptions BW-180C BW-180C MedChemExpress (MCE) HY-105343 63631-40-3 [D-Ala2, D-Leu5]-Enkephalin DADLE 99.92% Sealed storage, away from moisture Powder -80°C 2 years -20°C 1 year In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. BW-180C ([D-Ala2, D-Leu5]-Enkephalin DADLE) is an δ opioid receptor (DOR) agonist, which belongs to the enkephalin family. Neuroprotective agent. BW-180C reversibly inhibits cellular transcription in neurons without causing cell injury. "Pretreatment with BW-180C (DADLE) dose-dependently enhances survival of neurons in the central nervous system. BW-180C is able to induce a reversible hibernation-like state in HeLa cells, a cell line derived from cervical cancer cells, by inhibiting transcription and proliferation in these cells[1].BW-180C (100 pM to 10 μM) inhibits cellular transcription by ~50% by 24 h compared with vehicle-treated controls[1].BW-180C does not affect total RNA polymerase II expression. DADLE inhibits phosphorylation of RNA polymerase II in primary cortical neurons[1]. " BW-180C ( [D-Ala2, D-Leu5]-Enkephalin DADLE) protects liver against ischemia-reperfusion injury in the rat. DADLE (5 mg/kg) protects the heart, lung, and jejunum against ischemia-reperfusion (I-R) injury[2]. BW-180C (DADLE) improves hepatic ischemia/reperfusion injury in mice via activation of the Nrf2/HO1 pathway[3]. DADLE (5 mg/kg) significantly reduces the levels of alanine aminotransferase and aspartate aminotransferase in the serum, and the levels of malondialdehyde in the liver homogenate[3]. Opioid Receptor[1] Cellular Effect Cell Line Type Value Description References \| \| \| \| \| \| \| \| \| \| [1]. Jie Tian, et al. [D-Ala2, D-Leu5] encephalin (DADLE) reversibly inhibits cellular transcription in neurons without causing cell injury. Brain Res. 2014 May 27 1565:1-7. [Content Brief]* [2]. Kousyou Yamanouchi, et al. [D-Ala2, D-Leu5] enkephalin (DADLE) protects liver against ischemia-reperfusion injury in the rat. J Surg Res. 2003 Sep 114(1):72-7. [Content Brief] [3]. Zhou Y, et al. DADLE improves hepatic ischemia/reperfusion injury in mice via activation of the Nrf2/HO‑1 pathway. Mol Med Rep. 2017 Nov 16(5):6214-6221. [Content Brief]
Last Update	2025-04-01 14:45:47

MedChemExpress (MCE) also provides

Lysyllysine dihydrochloride

Category: Peptides
CAS: 52123-30-5
Last Update: 2025-04-01 14:45:47

Aureusimine B

Category: Peptides
CAS: 170713-71-0
Last Update: 2025-04-01 14:45:47

Cyclo(Pro-Val)

Category: Peptides
CAS: 5654-87-5
Last Update: 2025-04-01 14:45:47

Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2

Category: Peptides
CAS: 720710-69-0
Last Update: 2025-04-01 14:45:47

N,S-Bis-Fmoc-Glutathione

Category: Peptides
CAS: 149438-56-2
Last Update: 2025-04-01 14:45:47

Phe-Pro-Ala-pNA

Category: Peptides
CAS: 201738-99-0
Last Update: 2025-04-01 14:45:47

Cyclo(-Leu-Phe)

Category: Peptides
CAS: 7280-77-5
Last Update: 2025-04-01 14:45:47

H-γ-Glu-Leu-OH

Category: Peptides
CAS: 2566-39-4
Last Update: 2025-04-01 14:45:47


Supplier Name	MedChemExpress (MCE)
Contact	sales
Tel	609-228-6898
Mobile	609-228-6898
QQ
Email	sales@medchemexpress.com; tech@medchemexpress.com
Website	https://www.medchemexpress.com/
Wechat

Request for quotation

Supplier Contact