Genipin 1-β-D-gentiobioside MedChemExpress (MCE)

Product Name	Genipin 1-Gentiobioside
Synonyms	Genipin 1-Gentiobioside genipin 1-gentiobioside Genipin-1-O-gentiobioside genipin-1-β-D-gentiobioside Genipin-1-β-D-gentiobioside genipin-1-b-D-gentiobioside Genipin-1-b-D-gentiobioside Synonyms Genipin 1-Gentiobioside genipin 1-gentiobioside Genipin-1-O-gentiobioside genipin-1-β-D-gentiobioside Genipin-1-β-D-gentiobioside genipin-1-b-D-gentiobioside Genipin-1-b-D-gentiobioside Genipin 1-beta-gentiobioside Genipin 1-O-beta-D-gentiobioside methyl (1S,4aS,7aS)-1-[(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate Methyl (1S,4aS,7aS)-1-{[6-O-(beta-D-glucopyranosyl)-beta-D-glucopyranosyl]oxy}-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate Cyclopenta[c]pyran-4-carboxylicacid, 1-[(6-O-b-D-glucopyranosyl-b-D-glucopyranosyl)oxy]-1,4a,5,7a-tetrahydro-7-(hydroxyMethyl)-,Methyl ester, (1S,4aS,7aS)- cyclopenta[c]pyran-4-carboxylic acid, 1-[(6-O-beta-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]-1,4a,5,7a-tetrahydro-7-(hydroxymethyl)-, methyl ester, (1S,4aS,7aS)- methyl (1S,4aS,7aS)-7-(hydroxymethyl)-1-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-2-yl]oxy-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate
CAS	29307-60-6
EINECS
Chemical Formula	C23H34O15
Molecular Weight	550.51
inchi	InChI=1/C23H34O15/c1-33-20(32)10-6-34-21(13-8(4-24)2-3-9(10)13)38-23-19(31)17(29)15(27)12(37-23)7-35-22-18(30)16(28)14(26)11(5-25)36-22/h2,6,9,11-19,21-31H,3-5,7H2,1H3/t9-,11-,12-,13-,14-,15-,16+,17+,18-,19-,21+,22-,23+/m1/s1
Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Get quote
Descriptions	Genipin 1-β-D-gentiobioside Genipin 1-β-D-gentiobioside MedChemExpress (MCE) HY-N2094 29307-60-6 Genipin 1-gentiobioside Descriptions Genipin 1-β-D-gentiobioside Genipin 1-β-D-gentiobioside MedChemExpress (MCE) HY-N2094 29307-60-6 Genipin 1-gentiobioside Genipin 1-β-gentiobioside Genipin gentiobioside 99.73% 4°C, protect from light In solvent : -80°C, 6 months -20°C, 1 month (protect from light) Room temperature in continental US may vary elsewhere. Genipin 1-β-D-gentiobioside (Genipin 1-gentiobioside) is one of the most abundant and bioactive iridoid glycosides in Gardenia jasminoides Ellis, which possesses hepatoprotective, anti-inflammatory, antioxidant, and antithrombotic activities. Genipin 1-β-D-gentiobioside (Genipin gentiobioside) has moderate terminal elimination half-life (t1/2=1.65±0.87 h and 2.43±2.30 h for nomal rats (11.4 mg/kg) and cholestatic liver injury (CLI) rats (11.4 mg/kg), respectively)[1]. Rats[1] Twelve male rats are divided randomly into normal and acute cholestatic liver injury (CLI) group, with 6 rats in each. The rats are kept in an air-conditioned environment at a temperature of 22-24°C and a relative humidity of 50±10%, with access to the standard laboratory food and water. After fasted for 12 h, the rats are given Zhi-Zi-Da-Huang decoction (ZZDHD) at a dose of 8 g/kg (crude drug/body weight, equivalent to 35.9 mg/kg geniposide, 11.4 mg/kg Genipin 1-β-D-gentiobioside, 2.50 mg/kg Rhein, 0.23 mg/kg Emodin, 11.2 mg/kg Isonaringin, 83.5 mg/kg Naringin, 12.4 mg/kg Hesperidin and 79.6 mg/kg Neohesperidin) by oral administration. Blood samples (approximately 0.3 mL) are collected from the fosse orbital vein using heparinized 1.5 mL polythene tubes before the dose and at 0.08, 0.17, 0.33, 0.67, 1, 1.5, 2, 3, 4, 6, 8, 10, 12, 24, 36 and 48 h after dosing, and then centrifuged immediately at 13,000 rpm for 5 min. Plasma is transferred into clean tubes and stored at -80°C until analysis[1]. \| \| \| \| \| \| \| \| \| \| [1]. Zhu H, et al. Simultaneous determination of two iridoid glycosides, two anthraquinones and four flavonoid glycosides of Zhi-Zi-Da-Huang decoction in rat plasma by UFLC-MS/MS: application to a comparative pharmacokinetic study in normal and cholestatic liver injury rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Jun 1 960:116-25. [Content Brief]*
Last Update	2025-04-01 14:45:47

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