RGD peptide (GRGDNP) MedChemExpress (MCE)

Product Name	GRGDNP
Synonyms	GRGDNP;RGD PEPTIDE;RGD PEPTIDE (GRGDNP);GLY-ARG-GLY-ASP-ASN-PRO;Gly-Arg-Gly-Asp-Asn-Ser;H-GLY-ARG-GLY-ASP-ASN-PRO-OH;H-Glg-Arg-Gly-Asp-Asn-Pro-OH
CAS	114681-65-1
EINECS
Chemical Formula	C23H38N10O10
Molecular Weight	614.61
inchi
Package	1 mg;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Get quote
Descriptions	RGD peptide (GRGDNP) RGD peptide (GRGDNP) MedChemExpress (MCE) HY-P1740 114681-65-1 99.79% Sealed storage, away from moisture Powder -80°C 2 years -20°C 1 year In solvent : -80°C, 6 months Descriptions RGD peptide (GRGDNP) RGD peptide (GRGDNP) MedChemExpress (MCE) HY-P1740 114681-65-1 99.79% Sealed storage, away from moisture Powder -80°C 2 years -20°C 1 year In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. RGD peptide (GRGDNP) is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) plays an important role in cell adhesion, migration, growth, and differentiation. RGD peptide (GRGDNP) (50 μM preincubation for 3 hours before stretch) abolishes stretch-induced IKK activation and IL-6 mRNA expression. It shows little effect on the IKK activity and IL-6 mRNA expression in unstretched HUVECs[2]. RGD peptide (GRGDNP) (300?μg/mL for 6?hours) completely reverses enhanced FN1 expression in oxygen glucose deprivation(OGD) treated primary hippocampal neurons, HT22 cell lines and in its sEVs[3]. α5β1 Caspase 3 Gly-Arg-Gly-Asp-Asn-Pro \| \| \| \| \| \| \| \| \| \| [1]. C D Buckley, et al. RGD peptides induce apoptosis by direct caspase-3 activation. Nature. 1999 Feb 11 397(6719):534-9. [Content Brief] [2]. Wei Xia, et al. Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors. Nat Commun. 2021 Oct 15 12(1):6043. [Content Brief] [3]. Akitoshi Sasamoto, et al. Mechanotransduction by integrin is essential for IL-6 secretion from endothelial cells in response to uniaxial continuous stretch. Am J Physiol Cell Physiol. 2005 May 288(5):C1012-22. [Content Brief]
Last Update	2025-04-01 14:45:47

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