DL-Mevalonolactone MedChemExpress (MCE)

Product Name	DL-Mevalonic acid lactone
Synonyms	Beta-Hydro mevalonic lactone DL-MEVALONOLACTONE DL-Mevalonolactone ()-Mevalonolactone DL-Mevalonic acid lactone D,L-Mevalonic Acid delta-Lactone Synonyms Beta-Hydro mevalonic lactone DL-MEVALONOLACTONE DL-Mevalonolactone ()-Mevalonolactone DL-Mevalonic acid lactone D,L-Mevalonic Acid delta-Lactone dl-mevalonic acid lactone, salt-free 4-hydroxy-4-methyltetrahydro-2H-pyran-2-one (S)-4β-Hydroxy-4-methyltetrahydro-2H-pyran-2-one (S)-Tetrahydro-4-hydroxy-4-methyl-2H-pyran-2-one (4S)-4-Hydroxy-4-methyltetrahydro-2H-pyran-2-one (S)-3,5-Dihydroxy-3-methylpentanoic acid δ-lactone (±)-Mevalonolactone,(±)-β-Hydroxy-β-methyl-δ-valerolactone, (±)-3-Hydroxy-3-methyl δ-valerolactone, DL-Mevalolactone, DL-Mevalonic acid lactone β-Hydroxy-β-methyl-δ-valerolactone, (±)-β-Hydroxy-β-methyl-δ-valerolactone, (±)-3-Hydroxy-3-methyl δ-valerolactone, (±)-Mevalolactone, (±)-Mevalonic acid lactone, (±)-Mevalonolactone
CAS	674-26-0
EINECS	211-615-0
Chemical Formula	C6H10O3
Molecular Weight	130.14
inchi	InChI=1/C6H10O3/c1-6(8)2-3-9-5(7)4-6/h8H,2-4H2,1H3
Package	10 mM * 1 mL;100 mg;250 mg;500 mg
Price	Get quote
Descriptions	DL-Mevalonolactone DL-Mevalonolactone MedChemExpress (MCE) HY-107855 674-26-0 (±)-Mevalonolactone Descriptions DL-Mevalonolactone DL-Mevalonolactone MedChemExpress (MCE) HY-107855 674-26-0 (±)-Mevalonolactone Mevalolactone 99.15% Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. DL-Mevalonolactone ((±)-Mevalonolactone Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone is orally active against HMGCR mutation and statin caused myopathy. DL-Mevalonolactone induces inflammation and oxidative stress response with decreased mitochondrial membrane potential (MMP) and induces mitochondrial swelling[2][4]. DL-Mevalonolactone (0.1-1 mM, 0-72 h) induces inflammatory response with upregulated IL1B expression,induces oxidative stress with mitochondrial membrane depolarization and increased levels of SOD2, HemeOX and ROS[4]. DL-Mevalonolactone(1-2 mM) promotes peroxidation, inhibits activity of aconitase in brain[2]. DL-Mevalonolactone exhibits efficacy against statin induced myopathy in C57BL/6 mice (200 mg/kg, p.o. for 14 days), without toxicity (2 g/kg, p.o. for 7 days)[3]. Human Endogenous Metabolite \| \| \| \| \| \| \| \| \| \| [1]. Domingos SR, et al. On the structural intricacies of a metabolic precursor: Direct spectroscopic detection of water-induced conformational reshaping of mevalonolactone. J Chem Phys. 2017 Sep 28 147(12):124310. [Content Brief] [2]. Cecatto C, et al. Mevalonolactone disrupts mitochondrial functions and induces permeability transition pore opening in rat brain mitochondria: Implications for the pathogenesis of mevalonic aciduria. Neurochem Int. 2017 Sep 108:133-145. [Content Brief] [3]. Yogev Y, et al., Limb girdle muscular disease caused by HMGCR mutation and statin myopathy treatable with mevalonolactone. Proc Natl Acad Sci U S A. 2023 Feb 14 120(7):e2217831120. [Content Brief] [4]. Gratton R, et al., Prolonged treatment with mevalonolactone induces oxidative stress response with reactive oxygen species production, mitochondrial depolarization and inflammation in human glioblastoma U-87 MG cells. Neurochem Int. 2018 Nov 120:233-237. [Content Brief]
Supplier Website	https://www.medchemexpress.com/dl-mevalonolactone.html
Last Update	2025-05-21 16:50:25

MedChemExpress (MCE) also provides

Glycyl-L-glutamine

Category: Natural Products
CAS: 13115-71-4
Last Update: 2025-05-21 16:50:25

Triose phosphate

Category: Natural Products
CAS: 591-57-1
Last Update: 2025-05-21 16:50:25

Lactyl-CoA

Category: Natural Products
CAS: 1926-57-4
Last Update: 2025-05-21 16:50:25

12(S)-HPETE

Category: Natural Products
CAS: 71774-10-2
Last Update: 2025-05-21 16:50:25

Pyrithiamine

Category: Natural Products
CAS: 534-64-5
Last Update: 2025-05-21 16:50:25

alpha-CEHC

Category: Natural Products
CAS: 4072-32-6
Last Update: 2025-05-21 16:50:25

Maltoheptaose

Category: Natural Products
CAS: 34620-78-5
Last Update: 2025-05-21 16:50:25

Phenoxyethanol

Category: Natural Products
CAS: 122-99-6
Last Update: 2025-05-21 16:50:25


Supplier Name	MedChemExpress (MCE)
Contact	sales
Tel	609-228-6898
Mobile	609-228-6898
QQ
Email	sales@medchemexpress.com; tech@medchemexpress.com
Website	https://www.medchemexpress.com/
Wechat

Request for quotation

Supplier Contact