Aristeromycin MedChemExpress (MCE)

Product Name	Aristeromycin
Synonyms	ARISTEROMYCIN Aristeromycin Cycloadenosine 3-Aristeromycin 4'-O-Carbaadenosine 9-[2,3-DIHYDROXY-4-(HYDROXYMETHYL)CYCLOPENTYL]ADENINE (1r,2s,3r,5r)-3-(6-amino-9h-purin-9-yl)-5-(hydroxymethyl)-1,2-cyclopentanedi Synonyms ARISTEROMYCIN Aristeromycin Cycloadenosine 3-Aristeromycin 4'-O-Carbaadenosine 9-[2,3-DIHYDROXY-4-(HYDROXYMETHYL)CYCLOPENTYL]ADENINE (1r,2s,3r,5r)-3-(6-amino-9h-purin-9-yl)-5-(hydroxymethyl)-1,2-cyclopentanedi 1,2-cyclopentanediol,3-(6-amino-9h-purin-9-yl)-5-(hydroxymethyl)-,(1r,2s,3r,5 (1R,2S,3R,5R)-3-(6-Amino-9H-purin-9-yl)-5-(hydroxymethyl)-1,2-cyclopentanediol
CAS	19186-33-5
EINECS
Chemical Formula	C11H15N5O3
Molecular Weight	265.27
inchi
Package	10 mM * 1 mL;1 mg;5 mg
Price	Get quote
Descriptions	Aristeromycin Aristeromycin MedChemExpress (MCE) HY-112639 19186-33-5 99.34% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Aristeromycin Aristeromycin MedChemExpress (MCE) HY-112639 19186-33-5 99.34% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Aristeromycin, an adenosine analog, is an antibiotic and a potent S-adenosylhomocysteine hydrolase (AHCY) inhibitor. The IC50 value of Aristeromycin against AHCY is 38.5 nM at 50 μM S-adenosylhomocysteine (SAH) (approximately equal to the Km: 48 μM), but 271 nM at 1000 μM SAH (20× Km). With 60 min of preincubation, the mean IC50 value of Aristeromycin at 50 μM SAH is 12.7 nM[1]. Aristeromycin has IC50 values of 3.2 μM for LNCaP-FGC cell growth and 0.88 μM for LNCaP-hr cell growth[1]. At least in part, Aristeromycin can regulate oncogenic EZH2 expression by inducing miR-26a[1]. S-adenosylhomocysteine hydrolase[1] Cellular Effect Cell Line Type Value Description References \| \| \| \| \| \| \| \| \| \| [1]. Uchiyama N, et al. Aristeromycin and DZNeP cause growth inhibition of prostate cancer via induction of mir-26a. Eur J Pharmacol. 2017 Oct 5 812:138-146. [Content Brief] [2]. Ishikura T, et al. Inhibition of S-adenosylhomocysteine hydrolase by purine nucleoside analogues. Nucleic Acids Symp Ser. 1983 (12):119-22. [Content Brief]
Supplier Website	https://www.medchemexpress.com/aristeromycin.html
Last Update	2025-05-21 16:50:25

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