Meleagrin MedChemExpress (MCE)

Product Name	MELEAGRIN
Synonyms	MELEAGRIN;Meleagrine;6-O-Methyloxaline, Meleagrine
CAS	71751-77-4
EINECS	604-604-1
Chemical Formula	C23H23N5O4
Molecular Weight	433.46
inchi
Package	5 mg;10 mg;25 mg;1 mg
Price	Get quote
Descriptions	Meleagrin Meleagrin MedChemExpress (MCE) HY-N6797 71751-77-4 99.0% -20°C, protect from light In solvent : -80°C, 6 months Descriptions Meleagrin Meleagrin MedChemExpress (MCE) HY-N6797 71751-77-4 99.0% -20°C, protect from light In solvent : -80°C, 6 months -20°C, 1 month (protect from light) Room temperature in continental US may vary elsewhere. Meleagrin is a roquefortine C-derived alkaloid produced by fungi of the genus Penicillium and has antimicrobial and anti-proliferative activities. Meleagrin is a class of FabI inhibitor. Meleagrin is a lead c-Met inhibitory entity useful for the control of c-Met-dependent metastatic and invasive breast malignancies. Meleagrin inhibits the growth of the human breast cancer cell lines MDA-MB-231, MDA-468, BT-474, SK BR-3, MCF7 and MCF7-dox[3]. Meleagrin causes a dose-dependent inhibition of HGF-induced cell migration, and invasion of breast cancer cell lines[3]. Meleagrin potently suppresses the invasive triple negative breast tumor cell growth in an orthotopic athymic nude mice model[3]. \| \| \| \| \| \| \| \| \| \| [1]. Newmister SA, et al. Unveiling sequential late-stage methyltransferase reactions in the meleagrin/oxaline biosyntheticpathway. Org Biomol Chem. 2018 Sep 11 16(35):6450-6459. [Content Brief] [2]. Zheng CJ, et al. Meleagrin, a new FabI inhibitor from Penicillium chryosogenum with at least one additional mode of action. PLoS One. 2013 Nov 28 8(11):e78922. [Content Brief] [3]. Mady MS, et al. The indole alkaloid meleagrin, from the olive tree endophytic fungus Penicillium chrysogenum, as a novel lead for the control of c-Met-dependent breast cancer proliferation, migration and invasion. Bioorg Med Chem. 2016 Jan 15 24(2):113-22. [Content Brief]
Last Update	2025-04-01 14:45:47

MedChemExpress (MCE) also provides

Glycyl-L-glutamine

Category: Natural Products
CAS: 13115-71-4
Last Update: 2025-04-01 14:45:47

Triose phosphate

Category: Natural Products
CAS: 591-57-1
Last Update: 2025-04-01 14:45:47

Lactyl-CoA

Category: Natural Products
CAS: 1926-57-4
Last Update: 2025-04-01 14:45:47

12(S)-HPETE

Category: Natural Products
CAS: 71774-10-2
Last Update: 2025-04-01 14:45:47

Pyrithiamine

Category: Natural Products
CAS: 534-64-5
Last Update: 2025-04-01 14:45:47

alpha-CEHC

Category: Natural Products
CAS: 4072-32-6
Last Update: 2025-04-01 14:45:47

Maltoheptaose

Category: Natural Products
CAS: 34620-78-5
Last Update: 2025-04-01 14:45:47

Phenoxyethanol

Category: Natural Products
CAS: 122-99-6
Last Update: 2025-04-01 14:45:47


Supplier Name	MedChemExpress (MCE)
Contact	sales
Tel	609-228-6898
Mobile	609-228-6898
QQ
Email	sales@medchemexpress.com; tech@medchemexpress.com
Website	https://www.medchemexpress.com/
Wechat

Request for quotation

Supplier Contact