Apelin-13 MedChemExpress (MCE)

Product Name	GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE
Synonyms	QF-13 QRPRLSHKGPMPF PREPRO-65-77-APELIN apelin-13 trifluoroacetate salt Apelin-13, human, bovine, mouse, rat (2) GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH Synonyms QF-13 QRPRLSHKGPMPF PREPRO-65-77-APELIN apelin-13 trifluoroacetate salt Apelin-13, human, bovine, mouse, rat (2) GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH H-GLN-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE-OH L-Phenylalanine, L-glutaminyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl- Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe ((2) Due to the presence of a Gln in N-terMinal position this peptide can contain the pyroglutaMic forM)
CAS	217082-58-1
EINECS
Chemical Formula	C69H111N23O16S
Molecular Weight	1550.83
inchi
Package	1 mg
Price	Get quote
Descriptions	Apelin-13 Apelin-13 MedChemExpress (MCE) HY-P1944 217082-58-1 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US Descriptions Apelin-13 Apelin-13 MedChemExpress (MCE) HY-P1944 217082-58-1 Please store the product under the recommended conditions in the Certificate of Analysis. Room temperature in continental US may vary elsewhere. Apelin-13 is an endogenous ligand for the G-protein coupled receptor angiotensin II protein J (APJ), activating this G protein-coupled receptor with an EC 50 value of 0.37 nM. Apelin-13 is widely distributed in the central and peripheral nervous systems. Apelin-13 has vasodilatory and antihypertensive effects. Apelin-13 also can be used for researching type 2 diabetes and metabolic syndrome. Apelin-13 (200 µg/kg IP, daily for 4 weeks) improves cardiac function, improves insulin resistance, improves lipid metabolism, significantly decreases TNF-α and leptin on serum, induces the expression of Apelin-12 in serum and markedly elevates GLUT4 and p-AMPKα2 levels[2]. Apelin-13 (10 and 100 μM ICV, single dosage) increases the spontaneous discharges in the majority of pallidal neurons[4]. IC50: 0.37 nM (APJ)[1] In Vivo Apelin-13 (200 µg/kg IP, daily for 4 weeks) improves cardiac function, improves insulin resistance, improves lipid metabolism, significantly decreases TNF-α and leptin on serum, induces the expression of Apelin-12 in serum and markedly elevates GLUT4 and p-AMPKα2 levels[2]. Apelin-13 (10 and 100 μM ICV, single dosage) increases the spontaneous discharges in the majority of pallidal neurons[4]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Goto-Kakizaki (GK) rats (12 weeks old 240-280 g fed with a high-fat diet: 66.5% standard chow, 10% lard, 20% sucrose, 2.5% cholesterol and 1% pig bile salt)[2] Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe \| \| \| \| \| \| \| \| \| \| [1]. Tatemoto, K., Hosoya, M., Habata, Y., et al. Isolation and characterizaton of a novel endogenous peptide ligand for the human APJ receptor. Biochemical and Biophysical Research Communications 251, 471-476 (1998). [Content Brief] [2]. Li M,et al. Apelin 13 ameliorates metabolic and cardiovascular disorders in a rat model of type 2 diabetes with a high fat diet. Mol Med Rep. 2018 Dec 18(6):5784-5790. [Content Brief] [3]. Yamaleyeva LM, et al. Apelin-13 in blood pressure regulation and cardiovascular disease. Curr Opin Nephrol Hypertens. 2016 Sep 25(5):396-403. [Content Brief] [4]. Wang Y, et al. Apelin-13 regulates electrical activity in the globus pallidus and induces postural changes in rats. Neural Regen Res. 2021 Nov 16(11):2264-2268. [Content Brief]
Last Update	2025-04-01 14:45:47

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