Guggulsterone MedChemExpress (MCE)

Product Name	(Z)-Guggulsterone
Synonyms	Gugulipid GUGULSTERONE Guggulsterone CIS GUGGULSTERONE (Z)-Guggulsterone pregna-4,17-diene-3,16-dione Pregna-4,17-diene-3,16-dione Synonyms Gugulipid GUGULSTERONE Guggulsterone CIS GUGGULSTERONE (Z)-Guggulsterone pregna-4,17-diene-3,16-dione Pregna-4,17-diene-3,16-dione PREGNA-4,17(20)-DIENE-3,16-DIONE (17Z)-pregna-4,17-diene-3,16-dione CIS-4,17(20)-PREGNADIENE-3,16-DIONE 4,17(20)-(CIS)-PREGNADIEN-3,16-DIONE (17E)-Pregna-4,17(20)-diene-3,16-dione (8alpha,9beta,17E)-20-methoxypregna-4,17-diene-3,16-dione (8S,9R,10R,13S,14S,17E)-17-(1-methoxyethylidene)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15-decahydrocyclopenta[a]phenanthrene-3,16-dione
CAS	95975-55-6
EINECS	1308068-626-2
Chemical Formula	C21H28O2
Molecular Weight	312.45
inchi	InChI=1/C21H28O2/c1-4-16-19(23)12-18-15-6-5-13-11-14(22)7-9-20(13,2)17(15)8-10-21(16,18)3/h4,11,15,17-18H,5-10,12H2,1-3H3/b16-4+/t15-,17+,18+,20+,21-/m1/s1
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Get quote
Descriptions	Guggulsterone Guggulsterone MedChemExpress (MCE) HY-107738 95975-55-6 Z/E-Guggulsterone 99.95% 4°C, protect from light In solvent : -80°C, 2 years Descriptions Guggulsterone Guggulsterone MedChemExpress (MCE) HY-107738 95975-55-6 Z/E-Guggulsterone 99.95% 4°C, protect from light In solvent : -80°C, 2 years -20°C, 1 year (protect from light) Room temperature in continental US may vary elsewhere. Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. Guggulsterone, a farnesoid X receptor (FXR) antagonist, decreases CDCA-induced FXR activation with IC50s of 17 and 15 μM for Z- and E-Guggulsterone, respectively. Guggulsterone (0.5-20 μM 24 hours) suppresses TREM-1, TLR4 and TNF-α expression as well as the phosphorylation of IκBα and NF-κB p65 by LPS[2]. Guggulsterone (orally 100 mg/kg once per day for 8 days) significantly improved the survival rates of wild-type mice with TNBS-induced colitis[2]. JNK Caspase \| \| \| \| \| \| \| \| \| \| [1]. Shishodia S, et al. Guggulsterone for Chemoprevention of Cancer. Curr Pharm Des. 2016 22(3):294-306. [Content Brief] [2]. Che X, et al. Protective effects of guggulsterone against colitis are associated with the suppression of TREM-1 and modulation of macrophages. Am J Physiol Gastrointest Liver Physiol. 2018 Jul 1 315(1):G128-G139. [Content Brief]
Last Update	2025-04-01 14:45:47

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