N-Acetyl-D-mannosamine MedChemExpress (MCE)

Product Name	2-acetamido-2-deoxy-D-mannose
Synonyms	2-acetamido-2-deoxy-D-mannose 2-Acetylamino-2-deoxy-D-mannose 2-(Acetylamino)-2-deoxy-D-mannose N-Acetyl-D-mannosamine Monohydrate D-Mannose, 2-(acetylamino)-2-deoxy- N-[2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide Synonyms 2-acetamido-2-deoxy-D-mannose 2-Acetylamino-2-deoxy-D-mannose 2-(Acetylamino)-2-deoxy-D-mannose N-Acetyl-D-mannosamine Monohydrate D-Mannose, 2-(acetylamino)-2-deoxy- N-[2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide N-Acetyl-D-mannosamine, 2-(Acetylamino)-2-deoxy-D-mannopyranose Glucosamine Hydrochloride Impurity 1(Glucosamine Hydrochloride EP Impurity A)
CAS	3615-17-6
EINECS	222-790-8
Chemical Formula	C8H15NO6
Molecular Weight	221.21
inchi
Package	10 mM * 1 mL;100 mg
Price	Get quote
Descriptions	N-Acetyl-D-mannosamine N-Acetyl-D-mannosamine MedChemExpress (MCE) HY-128850 3615-17-6 N-Acetylmannosamine Descriptions N-Acetyl-D-mannosamine N-Acetyl-D-mannosamine MedChemExpress (MCE) HY-128850 3615-17-6 N-Acetylmannosamine ManNAc 98.0% 4°C, protect from light In solvent : -80°C, 6 months -20°C, 1 month (protect from light) Room temperature in continental US may vary elsewhere. N-Acetyl-D-mannosamine (ManNAc) is an oral active sialic acid precursor that can prevent hypertension by increasing sialylation of IgG, making it a promising candidate for cardiovascular disease research. Additionally, N-Acetyl-D-mannosamine can activate hypocretin (HCRT) gene expression in orexin neurons and improve neurodegeneration caused by aging, offering potential avenues for research in neurological disorders. N-Acetyl-D-mannosamine (administered orally in drinking water at a concentration of 1%, p.o., once daily for 16 weeks) can prevent obesity-induced hypertension in a high-fat diet-induced hypertensive mouse model by increasing the sialylation level of IgG glycans[3]. N-Acetyl-D-mannosamine (administered orally in drinking water at a dose of 2 g/kg, 4-6 mL per day, for 12 weeks) can reverse the reduction in sialylation in the kidneys and muscles of a GNE myopathy C57BL/6J mouse model with the knock-in (Gne p.M712T) mutation[4]. N-Acetyl-D-mannosamine (administered orally in drinking water at a concentration of 0.5%, ad libitum, for 8 weeks) improves synaptic transmission and Long-Term Potentiation (LTP) in 6-month-old and 14-month-old SAMR1 mice[4]。 Human Endogenous Metabolite \| \| \| \| \| \| \| \| \| \| [1]. Revilla-Nuin B, et al. Transport of N-acetyl-D-mannosamine and N-acetyl-D-glucosamine in Escherichia coli K1: effect on capsular polysialic acid production. FEBS Lett. 2002 Jan 30 511(1-3):97-101. [Content Brief]* [2]. Hayakawa K, et al. Reactivation of hyperglycemia-induced hypocretin (HCRT) gene silencing by N-acetyl-d-mannosamine in the orexin neurons derived from human iPS cells. Epigenetics. 2017 Sep 12(9):764-778. [Content Brief] [3]. Peng J, et al. Supplementation With the Sialic Acid Precursor N-Acetyl-D-Mannosamine Breaks the Link Between Obesity and Hypertension. Circulation. 2019 Dec 10 140(24):2005-2018. [Content Brief] [4]. Niethamer TK, et al. Oral monosaccharide therapies to reverse renal and muscle hyposialylation in a mouse model of GNE myopathy. Mol Genet Metab. 2012 Dec 107(4):748-55. [Content Brief] [5]. Taniguchi S, et al. Chronic administration of N-acetyl-D-mannosamine improves age-associated impairment of long-term potentiation in the senescence-accelerated mouse. Neurosci Lett. 2015 Jun 26 598:41-6. [Content Brief]
Last Update	2025-04-01 14:45:47

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