Polygalacic acid MedChemExpress (MCE)

Product Name	Polygalacic acid
Synonyms	Polygalacic Polygalacic acid Virgaureagenin G (4R)-2β,3β,16α,23-Tetrahydroxyolean-12-en-28-oic acid (2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid Olean-12-en-28-oicacid, 2,3,16,23-tetrahydroxy-, (2β,3β,4,16)- Synonyms Polygalacic Polygalacic acid Virgaureagenin G (4R)-2β,3β,16α,23-Tetrahydroxyolean-12-en-28-oic acid (2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid Olean-12-en-28-oicacid, 2,3,16,23-tetrahydroxy-, (2β,3β,4,16)- (2beta,3beta,16alpha)-2,3,16,23-tetrahydroxyolean-12-en-28-oic acid Polygalacic acid (2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid (2beta,3beta,5xi,16alpha,18alpha)-2,3,16,23-tetrahydroxyolean-12-en-28-oic acid Polygalacic acid or (2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid
CAS	22338-71-2
EINECS
Chemical Formula	C30H48O6
Molecular Weight	504.7
inchi	InChI=1/C30H48O6/c1-25(2)11-12-30(24(35)36)18(13-25)17-7-8-21-26(3)14-19(32)23(34)27(4,16-31)20(26)9-10-28(21,5)29(17,6)15-22(30)33/h7,18-23,31-34H,8-16H2,1-6H3,(H,35,36)/t18-,19-,20+,21+,22+,23-,26-,27-,28+,29+,30+/m0/s1
Package	1 mg;5 mg
Price	Get quote
Descriptions	Polygalacic acid Polygalacic acid MedChemExpress (MCE) HY-N0801 22338-71-2 98.92% 4°C, protect from light In solvent : -80°C, 6 months Descriptions Polygalacic acid Polygalacic acid MedChemExpress (MCE) HY-N0801 22338-71-2 98.92% 4°C, protect from light In solvent : -80°C, 6 months -20°C, 1 month (protect from light) Room temperature in continental US may vary elsewhere. Polygalacic acid, is a triterpene, isolated from the root of Polygala tenuifolia Willd. Polygalacic acid inhibits MMP expression. Polygalacic acid may have a therapeutic effect in Osteoarthritis (OA) treatment . Polygalacic acid exerts a significant neuroprotective effect on cognitive impairment, PA improves cholinergic system reactivity by inhibiting acetylcholinesterase (AChE) activity, increasing choline acetyltransferase (ChAT) activity, and elevating levels of acetylcholine (Ach) in the hippocampus and frontal cortex. Polygalacic acid (0-100 μM 24 hours) significantly decreases the mRNAexpressions of MMP-3, MMP-9, MMP-13, and COX-2, which are significantly increased by IL-1β, in a dose-dependent manner[1]. Polygalacic acid (0-100 μM 6 hours) decreases the expression of phosphor-p38, phosphor-Erk, and phosphor-Jnk induced by IL-1β, phosphor-p65 is not reduced by polygalacic acid[1]. AChE \| \| \| \| \| \| \| \| \| \| [1]. Guo C, et al. Neuroprotective effects of polygalacic acid on scopolamine-induced memory deficits in mice. Phytomedicine. 2016 Feb 15 23(2):149-55. [Content Brief] [2]. Xu K, et al. Polygalacic acid inhibits MMPs expression and osteoarthritis via Wnt/β-catenin and MAPK signal pathways suppression. Int Immunopharmacol. 2018 Oct 63:246-252. [Content Brief]
Supplier Website	https://www.medchemexpress.com/polygalacic-acid.html
Last Update	2025-05-21 16:50:25

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