Didanosine MedChemExpress (MCE)

Product Name	Didanosine
Synonyms	ddino bmy40900 nsc612049 Didansine Didanosine 2.3-Dideoxy dideoxyinosine Synonyms ddino bmy40900 nsc612049 Didansine Didanosine 2.3-Dideoxy dideoxyinosine DDI, Didanosine 2,3-Dideoxyinosine 2',3'-dideoxyinosine 2',3'-Dideoxy Inosine 2',3'-Dideoxy-D-inosine 2',3'-Dideoxy inosine(DDI) 9-[5-(hydroxymethyl)tetrahydrofuran-2-yl]-3,9-dihydro-6H-purin-6-one
CAS	69655-05-6
EINECS	614-994-4
Chemical Formula	C10H12N4O3
Molecular Weight	236.23
inchi	InChI=1/C10H12N4O3/c15-3-6-1-2-7(17-6)14-5-13-8-9(14)11-4-12-10(8)16/h4-7,15H,1-3H2,(H,11,12,16)
Package	10 mM * 1 mL;5 mg;10 mg;50 mg;100 mg
Price	Get quote
Descriptions	Didanosine Didanosine MedChemExpress (MCE) HY-B0249 69655-05-6 2',3'-Dideoxyinosine Descriptions Didanosine Didanosine MedChemExpress (MCE) HY-B0249 69655-05-6 2',3'-Dideoxyinosine ddI 99.45% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Didanosine (2',3'-Dideoxyinosine ddI) is a a potent and orally active dideoxynucleoside analogue, and also is a potent nucleoside reverse transcriptase inhibitor. Didanosine shows antiretroviral activity for HIV. Didanosine is converted by cellular enzymes to the active antiviral metabolite dideoxyadenosine triphosphate (dd-ATP) and the intracellular half life of dd-ATP varies from 8-24 hours[1]. Didanosine shows antiretroviral activity with IC50 value of 0.24-0.6 mg/L for HIV infection[3]. Didanosine (5, 10, 50, 100 ug/ml 24, 48 h) shows no significant inhibition of cell proliferation in IEC-6 cells[2]. Didanosine (100, 150 mg/kg p.o. daily for 7 days) decreases the length of duodenal and in jejunal villus in mouse[2]. \| \| \| \| \| \| \| \| \| \| [1]. Munir N.Nassar, et al. Analytical profiles of drug substances and excipients. Journals & Books, 1993, 185-227. [2]. Braga Neto MB, et al. Evaluation of HIV protease and nucleoside reverse transcriptase inhibitors on proliferation, necrosis, apoptosis in intestinal epithelial cells and electrolyte and water transport and epithelial barrier function in mice. BMC Gastroenterol. 2010 Aug 11 10:90. [Content Brief] [3]. Caroline M. Perry, et al. Didanosine. Drugs, 1999, 58, 1099-1135.
Last Update	2025-04-01 14:45:47

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