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Supplier Contact
 | |
| Supplier Name | BOC Sciences |
| Contact | Linna Green |
| Tel | +16314854226 |
| Mobile | +16314854226 |
| info@bocsci.com | |
| Website | https://www.bocsci.com/ |
| https://www.linkedin.com/company/boc-sciences | |
| Product Name | AZD9291 |
| Synonyms | AZD9291 AZD-9291 Mereletinib Osimertinib Intermediate 4 Mereletinib mesylate(AZD9291) Pharmaceutical Chemical Anticancer Drug Azd-9291 for for Lung Cancer 1421373-65-0 N-(2-{2-dimethylaminoethyl-methylamino}-4-methoxy-5-{[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide |
| CAS | 1421373-65-0 |
| EINECS | 629-848-5 |
| Chemical Formula | C28H33N7O2 |
| Molecular Weight | 499.61 |
| inchi | |
| Package | 2.5 g |
| Price | $365 |
| Descriptions | AZD-9291 AZD-9291 is a third-generation EGFR inhibitor, showed promise in preclinical studies and provides hope for patients with advanced lung cancers that have become resistant to existing EGFR inhibitors. AZD9291 is highly active in preclinical models and is well tolerated in animal models. AZD 9291 is an irreversible inhibitor of epidermal growth factor receptor (EGFR) sensitizing and T790M resistance mutations (IC50s = 15-17 nM) while sparing the wild-type form of the receptor (IC50 = 480 nM). It binds the related IGF1R and hERG receptors with significantly reduced potency (IC50s = 2.9 and 16.2 µM, respectively). |
| Supplier Website | https://www.bocsci.com/product/azd-9291-cas-1421373-65-0-462147.html |
| Last Update | 2025-04-30 11:27:47 |
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