Verapamil
维拉帕米(verapamil)
CAS: 52-53-9
化学式: C27H38N2O4
| 中文名 | 维拉帕米 |
| 英文名 | verapamil |
| 别名 | 异博定 戊脉胺 维拉帕米 戊脉胺 异博定 维拉帕米杂质P 维拉帕米杂质N 5-((3,4-二甲氧基苯乙基)甲基氨基)-2-(3,4-二甲氧基苯基)-2-异丙基戊腈 |
| 英文别名 | verapamil Verapamil 2-isopropyl- NSC 272306NA dl-Verapamil -2-isopropyl- 4-dimethoxy-alpha-(1-methylethyl)-l)- 5-((3,4-dimethoxyphenethyl)methylamino)-2-(3,4-dimethoxyphenyl)-2-isopropylv 2-[3,4-di(methoxy)phenyl]-5-[2-(3,4-dimethoxyphenyl)ethyl-methyl-amino]-2-isopropyl-pentanenitrile alpha-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile Benzeneacetonitrile, a-[3-[[2-(3,4-dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-a-(1-methylethyl)- (9CI) Benzeneacetonitrile, .alpha.-3-2-(3,4-dimethoxyphenyl)ethylmethylaminopropyl-3,4-dimethoxy-.alpha.-(1-methylethyl)- |
| CAS | 52-53-9 |
| EINECS | 200-145-1 |
| 化学式 | C27H38N2O4 |
| 分子量 | 454.61 |
| InChI | InChI=1/C27H37N2O4/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6/h9-12,17-18,20H,7-8,13-16H2,1-6H3 |
| 密度 | 1.1267 (rough estimate) |
| 熔点 | 25°C |
| 沸点 | 243-246 °C (1.3 Pa) |
| 折射率 | 1.5448 |
| 酸度系数 | 8.6(at 25℃) |
| 存储条件 | Keep in dark place,Inert atmosphere,Room temperature |
| 物化性质 | 粘稠的淡黄色油状液体。沸点243-246℃（1.3Pa），折光率（nD25）1.5448。溶于苯、醚，易溶于低级醇、丙酮、乙酸乙酯、氯仿，难溶于已烷，不溶于水。其盐酸盐（[152-11-4]）为白色至类白色结晶性粉末。熔点138.5-140.5℃（分解）。易溶于甲醇、二甲基甲酰胺，溶于乙醇、异丙醇、丙酮、乙酸乙酯，不溶于氯仿。无臭，味苦。 |
| 上游原料 | 苯甲醚 2-溴丙烷 溴丙烷 3,4-二甲氧基苯乙胺 |
| 下游产品 | 5-氨基-2-(3,4-二甲氧基苯基)-2-异丙基戊腈 N -甲基- 4 -(3,4 -二甲氧基苯基)- 4 -氰基- 5 - 己基甲胺 |
| 参考资料 展开查看 | 1. 李涛 赵小亮 聂颖兰 等. CQ止痛复方中青藤碱和川芎嗪的脑通透性研究[J]. 药学学报 2019 v.54(12):186-193. 2. 陆佳璐, 邓丽娜. 姜黄素-色氨酸共无定型的制备及其在大鼠体内的药动学研究[J]. 中国药房, 2019(17):2348-2354. 3. Wang, Jinli, et al. "In vitro synergistic effect of baicalin with azithromycin against Staphylococcus saprophyticus isolated from francolins with ophthalmia." Poultry science 98.1 (2019): 373-380.https://doi.org/10.3382/ps/pey356 4. Wang, Xin, et al. "Differences of first-pass effect in the liver and intestine contribute to the stereoselective pharmacokinetics of rhynchophylline and isorhynchophylline epimers in rats." Journal of ethnopharmacology 209 (2017): 175-183.https://doi.org/1 5. [IF=4.384] Rong Huang et al."Surfactant-free solid dispersion of BCS class IV drug in an amorphous chitosan oligosaccharide matrix for concomitant dissolution in vitro - permeability increase."Eur J Pharm Sci. 2019 Mar;130:147 6. [IF=4.36] Xin Wang et al."Differences of first-pass effect in the liver and intestine contribute to the stereoselective pharmacokinetics of rhynchophylline and isorhynchophylline epimers in rats."J Ethnopharmacol. 2017 Sep;209:175 7. [IF=3.667] Huang Yuanjia et al."Molecular cloning and characterization of calmodulin-like protein CaLP from the Scleractinian coral Galaxea astreata."Cell Stress Chaperon. 2018 Nov;23(6):1329-1335 8. [IF=1.627] Yanming Xia et al."Transport mechanism of ursodeoxycholic acid in human placental BeWo cells."Biopharm Drug Dispos. 2018 Jul;39(7):335-343 9. [IF=4.384] Juanhong Zhang et al."Enhanced P-glycoprotein expression under high-altitude hypoxia contributes to increased phenytoin levels and reduced clearance in rats."Eur J Pharm Sci. 2020 Oct;153:105490 10. [IF=3.352] Jinli Wang et al."In vitro synergistic effect of baicalin with azithromycin against Staphylococcus saprophyticus isolated from francolins with ophthalmia."Poultry Sci. 2019 Jan;98:373 11. [IF=3.981] Xiao-Hang Liu et al."Comparison of the permeability between conjugated estrogens and atenolol in rat in situ single-pass intestinal perfusions model and in Caco-2 cell monolayers."J Drug Deliv Sci Tec. 2022 Feb;68:102786 |
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产品名: 盐酸维拉帕米杂质45 (维拉帕米R异构体) 询盘
产地: 湖北
手机: 18186386804
电子邮件: 2885409035@qq.com
QQ: 2885409035
微信: 18186386804
产品描述: 290745V
产地: 湖北
手机: 18186386804
电子邮件: 2885409035@qq.com
QQ: 2885409035
微信: 18186386804
产品描述: 290745V
产品名: 盐酸维拉帕米杂质45 (维拉帕米R异构体) 询盘
产地: 湖北
手机: 18186386804
电子邮件: 2885409035@qq.com
QQ: 2885409035
微信: 18186386804
产品描述: 290745V
产地: 湖北
手机: 18186386804
电子邮件: 2885409035@qq.com
QQ: 2885409035
微信: 18186386804
产品描述: 290745V
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