中文名 | 人内皮素3 |
英文名 | endothelin 3 |
别名 | 人内皮素3 内皮素-3 小鼠内皮素-3 |
英文别名 | ENDOTHELIN-3 endothelin 3 ENDOTHELIN-3, HUMAN ENDOTHELIN 3 HUMAN, RAT ENDOTHELIN-III, HUMAN, RAT ENDOTHELIN 3, HUMAN AND RAT ENDOTHELIN-3 (HUMAN, RAT, PIG) ENDOTHELIN-3 (HUMAN, MOUSE, RABBIT, RAT) ENDOTHELIN-3 (HUMAN) (PORCINE, RAT, RABBIT) |
CAS | 117399-93-6 |
化学式 | C121H168N26O33S4 |
分子量 | 2643.04 |
密度 | 1.285±0.06 g/cm3(Predicted) |
存储条件 | −20°C |
外观 | 粉末 |
颜色 | white |
MDL号 | MFCD00076378 |
体外研究 | The endothelins (ETs) are a family of 21-amino-acid vasoconstrictor peptides comprising three distinct isoforms: ET-1, ET2 and Endothelin-3. Endothelin-3 is detected in plasma, heart, brain and vascular smooth muscle cells (VSMCs). The surface enzymes of VSMCs break down big Endothelin-3 to the corresponding mature peptide, Endothelin-3. Endothelin-3 down-regulate endothelin ETA receptor expression in coronary artery VSMCs without affecting receptor density or functional ETA receptor responses. By contrast, high concentrations of Endothelin-3 (100 nM) increase the expression of ETB receptors but abolish the vasoconstrictor response of the receptors, possibly due to the desensitizing effect of Endothelin-3. Endothelin-3 stimulates ENCC adhesion to various ECM components. Endothelin-3 induces rapid changes in ENCC shape and protrusion dynamics favouring sustained growth and stabilization of lamellipodia, a process coincident with the increase in the number of focal adhesions and activated β1-integrins. |
体内研究 | Endothelin-3 at low concentrations may attenuate inflammatory responses via ETB2 activation and NO production. Endothelin-3, which acts mainly on ETB, at low concentrations specifically inhibited platelet-activating factor (PAF)-induced paw oedema, whereas neither ET-1 nor Endothelin-2, both of which act on ETA and ETB, showed inhibitory activity. The inhibition by ET-1 and Endothelin-3 (each 0.5 pmol/paw) in the presence of BQ-123 (66.4 ± 6.7 % and 65.4 ± 22.6 %, respectively), is comparable to that by Endothelin-3 (0.5 pmol/paw) alone (65.4 ± 10.9 %), whereas neither ET-1 nor Endothelin-3 in the presence of BQ-788 showed inhibitory activity. |
安全术语 | 22 - 切勿吸入粉尘。 |
WGK Germany | 3 |
FLUKA BRAND F CODES | 3-10 |
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