凝血酶受体兴奋剂
凝血酶受体兴奋剂(ser-phe-leu-leu-arg-asn-pro-asn-asp-*lys-tyr-glu-)
CAS: 137339-65-2
化学式: C81H118N20O23
| 中文名 | 凝血酶受体兴奋剂 |
| 英文名 | ser-phe-leu-leu-arg-asn-pro-asn-asp-*lys-tyr-glu- |
| 别名 | 凝血酶受体激动剂 凝血酶受体兴奋剂 凝血酶受体活化因子肽 凝血酶受体激动剂肽-14 |
| 英文别名 | HUMAN TRAP HUMAN T-BAM HUMAN TNFSF5 HUMAN SCD40 LIGAND HUMAN SOLUBLE CD40 LIGAND thrombinreceptorpeptide(42-55 ser-phe-leu-leu-arg-asn-pro-asn-asp-*lys-tyr-glu- SER-PHE-LEU-LEU-ARG-ASN-PRO-ASN-ASP-*LYS -TYR-GLU-PR Ser-Phe-Leu-Leu-Arg-Asn-Pro-Asn-Asp-Lys-Tyr-Glu-Pro-Phe |
| CAS | 137339-65-2 |
| 化学式 | C81H118N20O23 |
| 分子量 | 1739.92 |
| InChI | InChI=1/C81H118N20O23/c1-43(2)34-53(93-71(114)54(35-44(3)4)94-73(116)55(92-67(110)49(83)42-102)36-45-16-7-5-8-17-45)70(113)90-51(21-13-31-88-81(86)87)69(112)98-59(40-64(85)105)79(122)101-33-15-22-61(101)76(119)97-57(39-63(84)104)74(117)96-58(41-66(108)109)75(118)89-50(20-11-12-30-82)68(111)95-56(37-47-24-26-48(103)27-25-47)72(115)91-52(28-29-65(106)107)78(121)100-32-14-23-62(100)77(120)99-60(80(123)124)38-46-18-9-6-10-19-46/h5-10,16-19,24-27,43-44,49-62,102-103H,11-15,20-23,28-42,82-83H2,1-4H3,(H2,84,104)(H2,85,105)(H,89,118)(H,90,113)(H,91,115)(H,92,110)(H,93,114)(H,94,116)(H,95,111)(H,96,117)(H,97,119)(H,98,112)(H,99,120)(H,106,107)(H,108,109)(H,123,124)(H4,86,87,88)/t49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,59-,60-,61-,62-/m0/s1 |
| 存储条件 | −20°C |
| 外观 | 白色至灰白色固体 |
| MDL号 | MFCD00133815 |
| 体外研究 | Thrombin cleaves its receptor at arginine-41, resulting in the generation of a new receptor NH2-terminus with the sequence Sfllrnpndkyepf. This peptide (TRP-14) may signal a variety of thrombin's responses. Sfllrnpndkyepf, representing the 14 amino acids starting with Ser-42 of the human thrombin receptor, was found to mimic the effect of thrombin on platelets. Cleavage of the human platelet thrombin receptor by thrombin exposes a new N-terminal which acts as a putative tethered ligand. Sfllrnpndkyepf, corresponding to the new N-terminal region, activates and induces platelet aggregation and serotonin secretion. Sfllrnpndkyepf is the minimal peptide length which retains full activity in inducing [ 14 C]serotonin secretion. TRAP induces rapid morphological changes in HUVECs, with marked increase in the release of prostacyclin, endothelin, platelet activating factor, tissue type plasminogen activator, and plasminogen activator inhibitor-1. Incubation of cells with TRAP also induces a rapid decrease in cell-surface thrombomodulin. |
| 危险品标志 | T - 有毒物品 |
| 风险术语 | 61 - 可能对胎儿造成伤害。 |
| 安全术语 | S53 - 避免接触，使用前须获得特别指示说明。 S45 - 若发生事故或感不适，立即就医(可能的话，出示其标签)。 |
| WGK Germany | 3 |
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