比阿培南
比阿培南(Biapenem)
CAS: 120410-24-4;155835-09-9
化学式: C15H18N4O4S
| 中文名 | 比阿培南 |
| 英文名 | Biapenem |
| 别名 | 比可培南 阿比培南 比阿培南 比亚培南 比阿培南杂质 比阿培南无菌粉 比阿培南比亚培南 比阿培南(标准品) 6-[[(4R,5S,6S)-2-羧基-6-((1R)-1-羟乙基)-4-甲基-7-氧代-1-氮杂双环[3.2.0]庚-2-烯-3-基]硫]-6,7-双氢-5H-哌唑酮[1,2-a][1,2,4]三氮杂-4-内盐 |
| 英文别名 | L-627 Biapenem BIAPENEM LJC-10627 6-[[(4R,5S,6S)-2-Carboxylato-6β-[(1R)-1-hydroxyethyl]-4α-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-5H-pyrazolo[1,2-a]-s-triazol-4-ium 6-[[(4R,5β)-2-Carboxylato-4α-methyl-6β-[(R)-1-hydroxyethyl]-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium (4R,5S,6S)-3-(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium-6-ylthio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate 6-({(4R,5S,6S)-2-carboxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl}sulfanyl)-6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium 6-[[(4R,5S,6S)-2-Carboxylato-6β-[(R)-1-hydroxyethyl]-4α-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium (4R,5S,6S)-3-(6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium-6-ylsulfanyl)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate 6-[[(4r,5s,6s)-2-carboxy-6-[(1r)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-5h-pyrazolo[1,2-a][1,2,4]triazol-4-ium inner salt |
| CAS | 120410-24-4 155835-09-9 |
| EINECS | 204-352-8 |
| 化学式 | C15H18N4O4S |
| 分子量 | 350.39 |
| InChI | InChI=1/C18H24N4O6/c1-8-12(20-4-3-5-23)15(25)11-9(7-28-17(19)26)18(27-2)16-10(21-16)6-22(18)13(11)14(8)24/h9-10,16,20-21,23H,3-7H2,1-2H3,(H2,19,26) |
| InChIKey | MRMBZHPJVKCOMA-YJFSRANCSA-N |
| 熔点 | 265-271°C (dec.) |
| 比旋光度 | D20 -32.9° (c = 0.5) |
| 溶解度 | H2O: ≥ 5mg/ml (温热) |
| 折射率 | 1.651 |
| 存储条件 | -20°C |
| 外观 | 粉末 |
| 颜色 | white to beige |
| WGK Germany | 3 |
| 参考资料 展开查看 | 1: Nakagawa Y, Suzuki K, Hirose T, Chou T, Fujisawa S, Kida M, Usuki K, Ishida Y, Taniguchi S, Kouzai Y, Tomoyasu S, Miyazaki K, Higashihara M, Ando K, Aoki S, Arai A, Akiyama N, Hatake K, Okamoto S, Dan K, Ohyashiki K, Urabe A. Erratum to: Clinical efficacy and safety of biapenem for febrile neutropenia in patients with underlying hematopoietic diseases: a multi-institutional study. J Infect Chemother. 2010 Dec 8. [Epub ahead of print] PubMed PMID: 21140280. 2: Jia B, Lu P, Huang W, Li C, Huang A, Zhou X, Zhang W, Wu G, Zhang G. A multicenter, randomized controlled clinical study on biapenem and imipenem/cilastatin injection in the treatment of respiratory and urinary tract infections. Chemotherapy. 2010;56(4):285-90. Epub 2010 Aug 11. PubMed PMID: 20714145. 3: Nakagawa Y, Suzuki K, Hirose T, Chou T, Fujisawa S, Kida M, Usuki K, Ishida Y, Taniguchi S, Kouzai Y, Tomoyasu S, Miyazaki K, Higashihara M, Ando K, Aoki S, Arai A, Akiyama N, Hatake K, Okamoto S, Dan K, Ohyashiki K, Urabe A. Clinical efficacy and safety of biapenem for febrile neutropenia in patients with underlying hematopoietic diseases: a multi-institutional study. J Infect Chemother. 2010 Jul 3. [Epub ahead of print] PubMed PMID: 20602137. 4: Kameda K, Ikawa K, Ikeda K, Morikawa N, Nakashima A, Ohge H, Sueda T. HPLC method for measuring meropenem and biapenem concentrations in human peritoneal fluid and bile: application to comparative pharmacokinetic investigations. J Chromatogr Sci. 2010 May-Jun;48(5):406-11. PubMed PMID: 205 |
比阿培南 - 配置溶液浓度参考
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.854 ml | 14.27 ml | 28.54 ml |
| 5 mM | 0.571 ml | 2.854 ml | 5.708 ml |
| 10 mM | 0.285 ml | 1.427 ml | 2.854 ml |
| 5 mM | 0.057 ml | 0.285 ml | 0.571 ml |
最后更新：2024-01-02 23:10:35
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产品名: 比阿培南 标准品 去供应商网站查看 询盘CAS: 120410-24-4
产地: 北京
包装: 瓶
规格: SB8660-20mg,20mg,IB0220-W-1ml,10mM*1ml( in Water),IB0220-10mg,10mg,IB0220-50mg,50mg
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库存: 现询
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产品描述: 产品覆盖：小分子化合物、分析对照品、染色试剂、生化试剂盒、细胞生物学、分子生物学、抗体、蛋白、多肽、ELISA试剂盒、微生物培养、化学合成、仪器耗材、CRO技术 更多
现货供应
产品名: 比阿培南 标准品 去供应商网站查看 询盘CAS: 120410-24-4
产地: 北京
包装: 瓶
规格: SB8660-20mg,20mg,IB0220-W-1ml,10mM*1ml( in Water),IB0220-10mg,10mg,IB0220-50mg,50mg
价格: 电话、微信、QQ、邮件
库存: 现询
电话: 010-50973130
手机: 18101056239(微信同号)
电子邮件: 3193328036@qq.com
QQ: 3193328036
微信: 18101056239
产品描述: 产品覆盖：小分子化合物、分析对照品、染色试剂、生化试剂盒、细胞生物学、分子生物学、抗体、蛋白、多肽、ELISA试剂盒、微生物培养、化学合成、仪器耗材、CRO技术 更多
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